|Project Title||Principal Investigator||Institution|
|ACE Center: Early detection and intervention in infants at risk for autism||Dawson, Geraldine||University of Washington|
|ACE Center: Eye-tracking studies of social engagement||Klin, Ami||Yale University|
|ACE Center: The development of the siblings of children with autism: A longitudinal study||Sigman, Marian||University of California, Los Angeles|
|Amygdala structure & biochemistry in adolescents with autism||Nacewicz, Brendon||University of Wisconsin - Madison|
|Analyses of brain structure and connectivity in young children with autism||Nordahl, Christine||University of California, Davis|
|A novel quantitative framework to study lack of social interactions in autism||Torres, Elizabeth||Rutgers, The State University of New Jersey - New Brunswick|
|A prospective multi-system evaluation of infants at risk for autism||Bauman, Margaret||Massachusetts General Hospital|
|A prospective multi-system evaluation of infants at risk for autism||Herbert, Martha||Massachusetts General Hospital|
|Autism: Social and communication predictors in siblings||Landa, Rebecca||Kennedy Krieger Institute|
|Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for idiopathic ASD||Kaufmann, Walter||Kennedy Krieger Institute|
|Automated measurement of facial expression in autism: Deficits in facial nerve function?||Messinger, Daniel||University of Miami|
|CDI-Type I: Understanding regulation of visual attention in autism through computational and robotic modeling||Scassellati, Brian||Yale University|
|Cellular structure of the amygdala in autism||Morgan, John||University of California, Davis|
|Child-initiated communicative interactions and autism intervention||Koegel, Robert||University of California, Santa Barbara|
|Child-initiated communicative interactions and autism intervention (supplement)||Koegel, Robert||University of California, Santa Barbara|
|Clinical and behavioral phenotyping of autism and related disorders||Swedo, Susan||National Institutes of Health|
|Collaborative research: Computational behavioral science: Modeling, analysis, and visualization of social and communicative behavior||Picard, Rosalind||Massachusetts Institute of Technology|
|Collaborative research: Computational behavioral science: Modeling, analysis, and visualization of social and communicative behavior||Rehg, James||Georgia Tech Research Corporation|
|Collaborative research: Computational behavioral science: Modeling, analysis, and visualization of social and communicative behavior||Sclaroff, Stan||Trustees of Boston University|
|Dey, Anind||Carnegie Mellon University|
|Forsyth, David||University of Illinois at Urbana-Champaign|
|Narayanan, Shrikanth||University of Southern California|
|Development of face processing in infants with autism spectrum disorders||Chawarska, Katarzyna||Yale University|
|Electrophysiological correlates of cognitive control in autism||Takarae, Yukari||University of California, Davis|
|Electrophysiological signatures of language impairment in autism spectrum disorder||Roberts, Timothy||Children's Hospital of Philadelphia|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015.
IACC Recommended Budget: $71,100,000 over 5 years
|1.L.B. Funding: The recommended budget was partially met.
Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.
Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.