Strategic Plan Objective Detail
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Question 2: Short-term Objective A  

$3,584,634.32
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.

Download 2009 Question 2: Short-term Objective A projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
A mitochondrial etiology of autism Wallace, Douglas University of California, Irvine
A non-human primate autism model based on maternal infection Patterson, Paul California Institute of Technology
A role for immune molecules in cortical connectivity: Potential implications for autism Elmer, Bradford University of California, Davis
Autism: Role of oxytocin Ellerbeck, Kathryn University of Kansas Medical Center
CD8 + T lymphocyte function in autism Ashwood, Paul University of California, Davis
CD8 + T lymphocyte function in autism Ashwood, Paul University of California, Davis
Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance Rall, Glenn The Fox Chase Cancer Center
Evaluation and treatment of copper/zinc imbalance in children with autism Ramer, Jeanette Penn State Milton S. Hershey Medical Center
Gene-environment interactions in the pathogenesis of autism-like neurodevelopmental damage: A mouse model Pletnikov, Mikhail Johns Hopkins University School of Medicine
How does IL-6 mediate the development of autism-related behaviors? Hsiao, Elaine California Institute of Technology
Immune molecules and cortical synaptogenesis: Possible implications for the pathogenesis of autism McAllister, A. Kimberley University of California, Davis
Impact of innate immunity on regressive autism Jyonouchi, Harumi University of Medicine & Dentistry of New Jersey
Impact of innate immunity on T and B cell differentiation in autistic children/Altered TLR response in a subset of children with regressive autism Jyonouchi, Harumi University of Medicine & Dentistry of New Jersey
Impact of innate immunity on T and B cell differentiation in autistic children/Altered TLR response in a subset of children with regressive autism Jyonouchi, Harumi University of Medicine & Dentistry of New Jersey
Influence of oxidative stress on transcription and alternative splicing of methionine synthase in autism Muratore, Christina Northeastern University
Is autism a mitochondrial disease? Giulivi, Cecilia University of California, Davis
Maternal infection and autism: Impact of placental sufficiency and maternal inflammatory responses on fetal brain development Palmer, Theo Stanford University
Maternal inflammation alters fetal brain development via tumor necrosis factor-alpha Carpentier, Pamela Stanford University
Mechanisms of mitochondrial dysfunction in autism Shoffner, John Georgia State University
Modulation of neuronal cysteine uptake and redox status by morphine, gluten/casein-derived opiates and naltrexone Deth, Richard Northeastern University School of Pharmacy
Neuroimmunologic investigations of autism spectrum disorders (ASD) Swedo, Susan National Institutes of Health (NIH)
Primate models of autism Bauman, Melissa University of California, Davis
Project 2: Immunological susceptibility of autism Van de Water, Judy University of California, Davis
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development Hepel, Maria State University of New York at Potsdam
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development Noble, Mark University of Rochester

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010 (Fever studies to be started by 2012).

IACC Recommended Budget: $9,800,000 over 4 years
2.2
$3,377,568
18 projects

2.S.A
$3,584,634
30 projects

2.S.A
$4,972,407
37 projects

2.S.A
$2,013,417
25 projects

2.S.A
$3,049,827
26 projects

$16,997,853
2.S.A. Funding: The recommended budget for this objective was met.

Progress: Many projects were funded in this area (approximately 20-30 per year), but the field is still developing, and emphasis on this objective should continue in the future. Scientific advances have been made in linking maternal innate immune function and immune-system challenge to aspects of ASD. Methodological advances in the field include the development of animal models for study of the role of the immune system in ASD and PET ligands for imaging microglial activation.

Remaining Gaps, Needs and Opportunities: There is a need for a well-designed, multi-site clinical study of clinical effects of fever and to develop standard measures of fever and behavioral/cognitive outcomes. Questions about fever could be integrated into funded epidemiological studies. There is also interest in further work on metabolic and mitochondrial issues, but in order for this work to be done, there is a need for validation and standardization of measures for assessment of oxidative stress and mitochondrial function. More guidance is needed on the key questions for this field to answer – a workshop to define these methodologies may be helpful. One of the key questions is to determine whether it is the body temperature associated with fever or some consequence of immune activation and production of the febrile state that leads to amelioration of cognitive function.