Strategic Plan Objective Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Question 2: Short-term Objective D  

$9,171,542.17
Fiscal Year: 2009

New! Yellow dot: Objective has some degree of funding, but less than the recommended amount.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2009 Question 2: Short-term Objective D projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Columbia University
A longitudinal MRI study of brain development in fragile X syndrome Hazlett, Heather Cody University of North Carolina at Chapel Hill
An adult brain-specific mouse model of neuronal TSC inactivation Kelleher, Raymond Massachusetts General Hospital
An investigation of neuropsychological endophenotypes in autism and fragile X Martin, Gary Everett University of North Carolina at Chapel Hill
Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo-controlled randomized study of donepezil Reiss, Allan Stanford University
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne Scripps Research Institute
BDNF and the restoration of spine plasticity with autism spectrum disorders Gall, Christine University of California, Irvine
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Cold Spring Harbor Laboratory
Cell type-based genomics of developmental plasticity in cortical GABA interneurons Huang, Z. Josh Cold Spring Harbor Laboratory
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Cold Spring Harbor Laboratory
Chromatin alterations in Rett syndrome Akbarian, Schahram University of Massachusetts Medical School
Clinical correlations of contiguous gene syndromes Potocki, Lorraine Baylor College of Medicine
Connectopathic analysis of autism Sanes, Joshua Harvard University
Coordinated control of synapse development by autism-linked genes Huber, Kimberly University of Texas Southwestern Medical Center
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Gibson, Jay University of Texas Southwestern Medical Center
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome (supplement) Gibson, Jay University of Texas Southwestern Medical Center
Developmental versus acute mechanisms mediating altered excitatory synaptic function in the fragile X syndrome mouse model Huber, Kimberly University of Texas Southwestern Medical Center
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Baylor College of Medicine
Elucidation of the developmental role of JAKMIP1, an autism-susceptibility gene Bomar, Jamee University of California, Los Angeles
Face processing and brain function associated with autistic symptoms in fragile X Dalton, Kim University of Wisconsin - Madison
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Emory University
Gene silencing in fragile X syndrome Usdin, Karen National Institutes of Health (NIH)
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Vanderbilt University
Genetics and physiology of social anxiety in fragile X Hessl, David University of California, Davis
High content screens of neuronal development for autism research Halpain, Shelley University of California, San Diego