|Project Title||Principal Investigator||Institution|
|ACE Center: Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|ACE Network: A comprehensive approach to identification of autism susceptibility genes||Geschwind, Daniel||University of California, Los Angeles|
|A genome-wide search for autism genes in the Simons Simplex Collection||State, Matthew||Yale University|
|A molecular genetic study of autism and related phenotypes in extended pedigrees||Piven, Joseph||University of North Carolina at Chapel Hill|
|Analysis of candidate genes derived from a protein interaction network in SSC samples||Zoghbi, Huda||Baylor College of Medicine|
|A recurrent genetic cause of autism||Gusella, James||Massachusetts General Hospital|
|Autism and SNPs in the IGF pathway||Levine, Arnold||Princeton University|
|Autism and the insula: Genomic and neural circuits||Allman, John||California Institute of Technology|
|Autism Genetic Resource Exchange (AGRE)||Staff Member||Autism Speaks (AS)|
|Autism Genome Project||Buxbaum, Joseph||Mount Sinai School of Medicine|
|Autism Genome Project (AGP)||Staff Member||Autism Speaks (AS)|
|Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy||Yang, Xiangdong||University of California, Los Angeles|
|Behavioral and genetic biomarker development for autism and related disorders||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Center for Genomic and Phenomic Studies in Autism||Lajonchere, Clara||University of Southern California|
|Clinical and Bioinformatics Core (supplement)||Pericak-Vance, Margaret||Duke University|
|Comprehensive follow-up of novel autism genetic discoveries||Daly, Mark||Massachusetts General Hospital|
|Comprehensive genetic variation detection to assess the role of the X chromosome in autism||Warren, Stephen||Emory University|
|Computational tools to analyze SNP data from patients with mental illness||Downey, Thomas||Partek, Inc.|
|Core--Genomics/Bioinformatics--Alzheimer's disease and autism||Gilliam, Thomas||Columbia University|
|Deep sequencing of autism candidate genes in 2000 families from the Simons Simplex Collection||Wigler, Michael||Cold Spring Harbor Laboratory|
|Dense mapping of candidate regions linked to autistic disorder||Gregersen, Peter||Feinstein Institute for Medical Research|
|Determining the genetic basis of autism by high-resolution analysis of copy number||Sebat, Jonathan||Cold Spring Harbor Laboratory|
|Epigenetic etiologies of autism spectrum disorders||LaSalle, Janine||University of California, Davis|
|Finding autism genes by genomic copy number analysis||Walsh, Christopher||Children's Hospital Boston|
|Gene expression profiling of autism spectrum disorders||Collins, Christin||Children's Hospital Boston|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.