3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.
Download 2009 Question 3: Short-term Objective A projects
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1/5-Elucidating the genetic architecture of autism by deep genomic sequencing Gibbs, Richard
Baylor College of Medicine
2/5-Elucidating the genetic architecture of autism by deep genomic sequencing Daly, Mark
Broad Institue, Inc.
3/5-Elucidating the genetic architecture of autism by deep genomic sequencing Buxbaum, Joseph
Mount Sinai School of Medicine
4/5-Elucidating the genetic architecture of autism by deep genomic sequencing Schellenberg, Gerard
University of Pennsylvania
5/5-Elucidating the genetic architecture of autism by deep genomic sequencing Sutcliffe, James
A systems biology approach to unravel the underlying functional modules of ASD Iakoucheva, Lilia
University of California, San Diego
Biological correlates of altered brain growth in autism Vaccarino, Flora
Genetic study of restricted repetitive behavior in autism spectrum disorders Kim, Soo-Jeong
University of Florida
Genomic profiling and functional mutation analysis in autism spectrum disorders State, Matthew
Human autism genetics and activity-dependent gene activation Walsh, Christopher
Children's Hospital Boston
Neural and phenotypic correlates of autism risk genes Bookheimer, Susan
University of California, Los Angeles