Strategic Plan Objective Detail
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Question 1: Objective 4  

$5,773,202.52
Fiscal Year: 2008

Yellow dot: Objective has some degree of funding, but less than the recommended amount.1.4 Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Download 2008 Question 1: Objective 4 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Autism: Social and communication predictors in siblings Landa, Rebecca Kennedy Krieger Institute
Automated measurement of facial expression in autism: Deficits in facial nerve function? Messinger, Daniel University of Miami
Clinical and behavioral phenotyping of autism and related disorders Swedo, Susan National Institutes of Health
Development of categorization + facial knowledge in low + high functioning autism - NIH Strauss, Mark University of Pittsburgh
Development of categorization and facial knowledge in infants at-risk for autism - AS Strauss, Mark University of Pittsburgh
Early detection and intervention in infants at risk for autism Dawson, Geraldine University of Washington
Emotion, communication, & EEG: Development & risk Messinger, Daniel University of Miami
Ethnicity and the elucidation of autism endophenotypes Constantino, John Washington University in St. Louis
Executive functioning, theory of mind, and neurodevelopmental outcomes Warren, Zachary Vanderbilt University Medical Center
Imitation in autism Bolton, Patrick King's College, London
Integrated function/structure image analysis in autism Duncan, James Yale University
Language processing in children with 22q11 deletion syndrome and autism Ousley, Opal Emory University
Motor control in young children with autism Hass, Christopher University of Florida
Scales, procedures, and intervention programs for estimating the prevalence of childhood disability and autism in Bangladesh Khan, Naila Dhaka Shishu (Children's) Hospital, Bangladesh Institute of Child Health
Sleep, neuropsychological, mood, behavior, learning, and developmental problems in children with autism Mayes, Susan Penn State College of Medicine
Temperament, emotional expression, and emotional self-regulation in relation to later ASD diagnosis Wozniak, Robert Bryn Mawr College
The early identification of temperament endophenotypes in ASD Bryson, Susan Dalhousie University
Understanding the cognitive impact of early life epilepsy Jensen, Frances Boston Children's Hospital

Objective Cumulative Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015.

IACC Recommended Budget: $71,100,000 over 5 years
1.4
$5,773,203
18 projects

1.L.B
$8,760,010
34 projects

1.L.B
$15,228,060
52 projects

1.L.B
$9,376,400
42 projects

1.L.B
$12,813,396
39 projects

$51,951,069
1.L.B. Funding: The recommended budget was partially met.

Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.

Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.