Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

$13,162,905.00
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Children's Hospital Boston
TrkB agonist(s), a potential therapy for autism spectrum disorders Sun, Yi University of California, Los Angeles
Translation regulation in hippocampal LTP and LTD Klann, Eric New York University
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan University of California, San Diego
The role of MeCP2 in Rett syndrome LaSalle, Janine University of California, Davis
The role of intracellular metabotropic glutamate receptor 5 at the synapse Hogan, Carolyn Washington University in St. Louis
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao University of Massachusetts Medical School
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao J. David Gladstone Institutes
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku University of Washington
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Children's Memorial Hospital, Chicago
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles University of Illinois at Urbana Champaign
Study of fragile X mental retardation protein in synaptic function and plasticity Huber, Kimberly University of Texas Southwestern Medical Center
Sex differences in early brain development; Brain development in Turner syndrome Santelli, Rebecca University of North Carolina at Chapel Hill
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Washington University in St. Louis
Regulation of synapse elimination by FMRP Wilkerson, Julia University of Texas Southwestern Medical Center
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony The George Washington University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony University of North Carolina at Chapel Hill
Quantitative proteomic approach towards understanding and treating autism Jin, Peng Emory University
Proteomics in drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence University of Tennessee Health Science Center
Probing disrupted cortico-thalamic interactions in autism spectrum disorders Fagiolini, Michela; Chen, Chinfei Children's Hospital Boston
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University
Presynaptic fragile X proteins Akins, Michael Brown University
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Johns Hopkins University
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Dana-Farber Cancer Institute
Neuronal activity-dependent regulation of MeCP2 (supplement) Greenberg, Michael Harvard Medical School