|Project Title||Principal Investigator||Institution|
|The genetic link between autism and structural cerebellar malformations||Millen, Kathleen||University of Chicago|
|The genetic basis of mid-hindbrain malformations||Dobyns, William||Seattle Children's Hospital|
|The brain genomics superstruct project||Buckner, Randy||President & Fellows of Harvard College|
|Social processing, language, and executive functioning in twin pairs: Electrophysiological and behavioral endophenotypes||Webb, Sara||University of Washington|
|Social cognition in 22q11.2 deletion syndrom (DS) adolescents with ASD vs. without ASD: Imaging and genetic correlates||Radoeva, Petya||State University of New York Upstate Medical University|
|Simons Variation in Individuals Project (VIP) Site||Bernier, Raphael||University of Washington|
|Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift||Chung, Wendy||Columbia University|
|Simons Variation in Individuals Project (Simons VIP) Core Leader Gift||Sherr, Elliott||University of California, San Francisco|
|Simons Variation in Individuals Project (Simons VIP)||Lese Martin, Christa||Emory University|
|Simons Variation in Individual Project (Simons VIP) Core Leader Gift||Hanson, Ellen||Children's Hospital Boston|
|Relating copy number variants to head and brain size in neuropsychiatric disorders||Sebat, Jonathan||University of California, San Diego|
|Neurogenic growth factors in autism||Vaccarino, Flora||Yale University|
|Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD||Monk, Christopher||University of Michigan|
|Neural correlates of restricted, repetitive behaviors in autism spectrum disorders||Manoach, Dara||Massachusetts General Hospital|
|Neural correlates of restricted, repetitive behaviors in autism spectrum disorders||Santangelo, Susan||Massachusetts General Hospital|
|Neural circuitry of social cognition in the broad autism phenotype||Piven, Joseph||University of North Carolina at Chapel Hill|
|Neural and phenotypic correlates of autism risk genes||Bookheimer, Susan||University of California, Los Angeles|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement)||Dulawa, Stephanie||University of Chicago|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models||Dulawa, Stephanie||University of Chicago|
|Longitudinal neurogenetics of atypical social brain development in autism||Pelphrey, Kevin||Yale University|
|Language processing in children with 22q11 deletion syndrome and autism||Ousley, Opal||Emory University|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Functional imaging of flexibility in autism: Informed by SLC6A4||Yerys, Benjamin||Children's Research Institute|
|fMRI evidence of genetic influence on rigidity in ASD||Lee, Jillian||University of Michigan|
|Characterizing the genetic systems of autism through multi-disease analysis||Wall, Dennis||Harvard Medical School|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.
IACC Recommended Budget: $22,600,000 over 5 years
|2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.
Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.