|Project Title||Principal Investigator||Institution|
|ACE Center: Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition||Geschwind, Daniel||University of California, Los Angeles|
|ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes||Cook, Edwin||University of Illinois at Chicago|
|A family-genetic study of language in autism||Losh, Molly||Northwestern University|
|A family-genetic study of language in autism||Losh, Molly||University of North Carolina at Chapel Hill|
|A multigenerational longitudinal study of language development: Insight from autism||Losh, Molly||University of North Carolina at Chapel Hill|
|A multigenerational longitudinal study of language development: Insight from autism||Losh, Molly||Northwestern University|
|A neuroimaging study of twin pairs with autism||Hardan, Antonio||Stanford University|
|An investigation of the overlap of autism and fragile X syndrome||Martin, Gary||University of North Carolina at Chapel Hill|
|Autism: Neuropeptide hormones and potential pathway genes||Jacob, Suma||University of Illinois at Chicago|
|Autism: Neuropeptide hormones and potential pathway genes (supplement)||Jacob, Suma||University of Illinois at Chicago|
|Autism: The neural substrates of language in siblings||Lindgren, Kristen||Boston University Medical Campus|
|Autistic traits: Life course & genetic structure||Constantino, John||Washington University|
|Behavioral and genetic biomarker development for autism and related disorders||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Characterizing the genetic systems of autism through multi-disease analysis||Wall, Dennis||Harvard Medical School|
|fMRI evidence of genetic influence on rigidity in ASD||Lee, Jillian||University of Michigan|
|Functional imaging of flexibility in autism: Informed by SLC6A4||Yerys, Benjamin||Children's Research Institute|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Language processing in children with 22q11 deletion syndrome and autism||Ousley, Opal||Emory University|
|Longitudinal neurogenetics of atypical social brain development in autism||Pelphrey, Kevin||Yale University|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models||Dulawa, Stephanie||University of Chicago|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement)||Dulawa, Stephanie||University of Chicago|
|Neural and phenotypic correlates of autism risk genes||Bookheimer, Susan||University of California, Los Angeles|
|Neural circuitry of social cognition in the broad autism phenotype||Piven, Joseph||University of North Carolina at Chapel Hill|
|Neural correlates of restricted, repetitive behaviors in autism spectrum disorders||Manoach, Dara||Massachusetts General Hospital|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.
IACC Recommended Budget: $22,600,000 over 5 years
|2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.
Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.