Strategic Plan Objective Detail
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Question 3: Objective 8  

$37,043,409.82
Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2008 Question 3: Objective 8 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Vasopressin receptors and social attachment Young, Larry Emory University
Unraveling the genetic etiology of autism Sutcliffe, James Vanderbilt University
Understanding glutamate signaling defects in autism spectrum disorders Wang, Tao Johns Hopkins University
Uncovering genetic mechanisms of ASD Kunkel, Louis Boston Children's Hospital
Translational genetic studies in familial ASDs Morrow, Eric Massachusetts General Hospital
The role of the Rett gene, chromosome 15q11-q13, other genes, and epigenetics Beaudet, Arthur Baylor College of Medicine
The role of MECP2 in Rett syndrome - Supplement LaSalle, Janine University of California, Davis
The role of MECP2 in Rett syndrome LaSalle, Janine University of California, Davis
The role of Contactin-associated Protein-like 2 (CNTNAP2) and other novel genes in autism Chakravarti, Aravinda Johns Hopkins University School of Medicine
The impact of autism specific genomic variations on microRNA gene expression profile Scherer, Stephen The Hospital for Sick Children
Studies of postmortem brain searching for epigenetic defects causing autism Beaudet, Arthur Baylor College of Medicine
Simons Simplex Collection Site - 9 Lord, Catherine University of Michigan
Simons Simplex Collection Site - 8 Ledbetter, David Emory University
Simons Simplex Collection Site - 7 Klin, Ami Yale University
Simons Simplex Collection Site - 6 Geschwind, Daniel University of California, Los Angeles
Simons Simplex Collection Site - 5 Fombonne, Eric The Research Institute of the McGill University Health Centre
Simons Simplex Collection Site - 4 Cook, Edwin University of Illinois at Chicago
Simons Simplex Collection Site - 3 Constantino, John Washington University in St. Louis
Simons Simplex Collection Site - 2 Bernier, Raphael University of Washington
Simons Simplex Collection Site - 14 Deutsch, Curtis University of Massachusetts Medical School
Simons Simplex Collection Site - 13 Walsh, Christopher Boston Children's Hospital
Simons Simplex Collection Site - 12 Sutcliffe, James Vanderbilt University
Simons Simplex Collection Site - 11 Peterson, Bradley Columbia University
Simons Simplex Collection Site - 10 Miles, Judith University of Missouri
Simons Simplex Collection Site - 1 Beaudet, Arthur Baylor College of Medicine

Objective Cumulative Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.