|Project Title||Principal Investigator||Institution|
|Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure||Keller, Flavio||Universita Campus Bio-Medico di Roma|
|Gene expression and immune cell function in mothers of children with autism||Sharp, Frank||University of California, Davis|
|Immune biomarkers in serum and newborn dried blood spots||Vogt, Robert||Centers for Disease Control and Prevention (CDC)|
|Maternal immune activation, cytokines, and the pathogenesis of autism||McAllister, A. Kimberley||University of California, Davis|
|Maternal risk factors for autism spectrum disorders in children of the Nurses' Health Study II||Ascherio, Alberto||Harvard University|
|Maternal risk factors for autism spectrum disorders in children of the Nurses' Health Study II||Santangelo, Susan||Massachusetts General Hospital|
|Maternal risk factors for autism spectrum disorders in children of the Nurses' Health Study II||Weisskopf, Marc||Harvard University|
|Maternal supplementation of folic acid and function of autism gene synaptic protein Shank3 in animal model||Jiang, Yong-Hui||Baylor College of Medicine|
|Project 1: Environmental epidemiology of autism||Hertz-Picciotto, Irva||University of California, Davis|
|Social determinants of the autism epidemic||Bearman, Peter||Columbia University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the prenatal and early postnatal period of development by 2015.
IACC Recommended Budget: $25,100,000 over 7 years
|3.L.C. Funding: The recommended budget was partially met, and several projects were funded, but it appears there is a downward trend in funding for these projects over time. This objective partially overlaps with 3.L.A.
Progress: Epidemiological studies coded to other objectives (e.g., EARLI) may also represent progress in this area.
Remaining Gaps, Needs, and Opportunities: A barrier to the completion of this objective is the undefined nature of ASD subtypes, both phenotypically and etiologically, lack of prenatal samples, and the lack of longitudinal follow-up of at-risk subgroups. This field is still developing and needs support.