Strategic Plan Objective Detail
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Question 3: Short-term Objective H  

$1,527,866.00
Fiscal Year: 2010

New! Yellow dot: Objective has some degree of funding, but less than the recommended amount.3SH. Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include: o Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and o Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings. oEmphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations. IACC Recommended Budget: $12,000,000 over 5 years.

Download 2010 Question 3: Short-term Objective H projects (EXCEL)
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Project Title Principal Investigator Institution
Structural and functional neural correlates of early postnatal deprivation Behen, Michael Wayne State University
Prenatal factors and risk of autism in a Finnish national birth cohort Brown, Alan New York State Psychiatric Institute
Multi-registry analyses for iCARE- West Australia Leonard, Helen The University of Western Australia
Multi-registry analyses for iCARE- Sweden Hultman, Christina Karolinska Institutet
Multi-registry analyses for iCARE - Norway Stoltenberg, Camilla Norwegian Institute of Public Health
Multi-registry analyses for iCARE - Israel Gross, Raz The Gertner Institute of Epidemiology and Health Policy Research
Multi-registry analyses for iCARE - Finland Sourander, Andre Turku University
Multi-registry analyses for iCARE - Denmark Parner, Eric Aarhus University
Multi-registry analyses for iCARE - Data Management Core Bresnahan, Michaeline Columbia University
Epidemiologic studies of reproductive and developmental outcomes – Denmark Olsen, Jorn Aarhus University
Epidemiological research on autism in Jamaica Rahbar, Mohammad University of Texas Health Science Center at Houston
Effect of oxytocin receptor inhibitor (atosiban) during the perinatal period and prevalence of autism spectrum disorders Ebstein, Richard Hebrew University
Assisted reproductive treatments and risk of autism Reichenberg, Avi Institute of Psychiatry, King's College London

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include:
  • Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and
  • Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings.
Emphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations.

IACC Recommended Budget: $12,000,000 over 5 years
N/A

N/A

3.S.H
$1,527,866
13 projects

3.S.H
$4,657,095
16 projects

3.S.H
$4,096,317
13 projects

$10,281,278
3.S.H. Funding: The recommended budget was partially met, and is approaching the recommended budget.

Progress: The funded projects cover the objective well; there are 32 projects that are related to this objective, though more projects focus on use of databases than on special populations. A positive element of progress for this objective is the existence of large monitoring databases and projects that capitalize on those resources, such as iCARE and MINERvA.

Remaining Gaps, Needs, and Opportunities: While progress is being made in this area, and it must be maintained in order to achieve this objective.