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Question 3: Short-term Objective J  

$5,072,389.28
Fiscal Year: 2010

New! Green dot: Objective has greater than or equal to the recommended funding.3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Download 2010 Question 3: Short-term Objective J projects (EXCEL)
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Project Title Principal Investigator Institution
Toxicant-induced autism and mitochondrial modulation of nuclear gene expression Wlodarczyk, Bogdan Texas A&M University
The role of the Rett gene, chromosome 15q11-q13, other genes, and epigenetics Beaudet, Arthur Baylor College of Medicine
Studies of postmortem brain searching for epigenetic defects causing autism Beaudet, Arthur Baylor College of Medicine
Maternal supplementation of folic acid and function of autism gene synaptic protein Shank3 in animal model Jiang, Yong-Hui Baylor College of Medicine
In vivo function of neuronal activity-induced MeCP2 phosphorylation Chang, Qiang University of Wisconsin - Madison
Identification of aberrantly methylated genes in autism: The role of advanced paternal age Gingrich, Jay Research Foundation for Mental Hygiene, Inc.
Identical twins discordant for autism: Epigenetic (DNA methylation) biomarkers of non-shared environmental influences Plomin, Robert King's College London
Human neurobehavioral phenotypes associates with the extended PWS/AS domain Beaudet, Arthur Baylor College of Medicine
Genome-wide analyses of DNA methylation in autism Chess, Andrew Massachusetts General Hospital
Epigenetic regulation of the autism susceptibility gene, ENGRAILED 2 (EN2) Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Epigenetic marks as peripheral biomarkers of autism Warren, Stephen Emory University
Environment, the perinatal epigenome, and risk for autism and related disorders Fallin, Margaret; Feinberg, Andrew Johns Hopkins University
DNA methylation and other epigenetic studies of autism brain Beaudet, Arthur Baylor College of Medicine
Discordant monozygotic twins as a model for genetic-environmental interaction in autism Feinberg, Andrew Johns Hopkins University
Discordant monozygotic twins as a model for genetic-environmental interaction in autism Kaufmann, Walter Kennedy Krieger Institute