Strategic Plan Objective Detail
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Office of Autism Research Coordination (OARC) logo

Question 4: Objective 2  

$4,583,171.00
Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.4.2 Support at least three randomized controlled trials that address co-occurring medical conditions associated with ASD by 2010. IACC Recommended Budget: $13,400,000 over 3 years.

Download 2008 Question 4: Objective 2 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Treatment of sleep problems in children with autism spectrum disorder with melatonin: A double-blind, placebo-controlled study Hopkins, Bobbi Baylor College of Medicine
Melatonin for sleep in children with autism: Safety, tolerability, and dosing Malow, Beth Vanderbilt University
Clinical trial: Modulation of prefrontal activity to improve language skills in autism spectrum disorder Pascual-Leone, Alvaro Beth Israel Deaconess Medical Center
Autistic enterocolitis/Crohns Balzola, Frederico University of Turin
Autism Intervention Research network on Physical health (AIR-P network) Perrin, James Massachusetts General Hospital

Objective Cumulative Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Support at least three randomized controlled trials that address co-occurring medical conditions associated with ASD by 2010.

IACC Recommended Budget: $13,400,000 over 3 years
4.2
$4,583,171
5 projects

4.S.A
$4,733,841
6 projects

4.S.A
$3,787,700
4 projects

4.S.A
$1,826,542
4 projects

4.S.A
$2,174,124
3 projects

$17,105,378
4.S.A. Funding: The recommended budget for this objective was met.

Progress: More than three projects were funded, including trials of sleep, anxiety, seizure and gastrointestinal (GI) interventions, meeting the objective. Additional work will be needed in the future to fully address these conditions.

Remaining Gaps, Needs, and Opportunities: Sleep issues, anxiety, hyperactivity and GI issues are key co-occurring medical conditions in patients with ASD.  Although there is much more known today about sleep initiation than what was understood 5 years ago, there is little understanding of what interventions/treatments are effective for sleep maintenance or night awakening. There is not much known concerning anxiety treatments for those with ASD, and challenges exist regarding the adaptation of anxiety treatments from outside ASD patient groups. Research into interventions for hyperactivity may be transferred from populations outside of those with ASD (i.e., ADHD). Though there has been an increased awareness of gastrointestinal difficulties and common symptoms among people with ASD, little is known about the etiology of autism-related GI issues. More research on the etiology of GI issues will be needed to develop appropriate treatments/interventions.