Strategic Plan Objective Detail
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Question 4: Objective 5  

$15,879,826.98
Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2008 Question 4: Objective 5 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Whitehead Institute for Biomedical Research
The role of Shank3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
The functional neuroanatomy of memory systems in the human brain Martin, Alex National Institutes of Health
Testing the effects of cortical disconnection in non-human primates Krauzlis, Richard Salk Institute for Biological Studies
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Duke University Medical Center
Steroid receptors and brain sex differences Auger, Anthony University of Wisconsin - Madison
Role of Wnt signaling through Dishevelled, Dact and p120catenin in forebrain development, synaptic physiology, and mouse behavior: Exploration of a pathway with many components linked to autism spectrum disorders Reichardt, Louis University of California, San Francisco
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Duke University
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Regulation of synaptogenesis by cyclin dependent kinase 5 Tsai, Li-Huei Massachusetts Institute of Technology
Regulation of MET expression in autism disorder and forebrain ontogeny Bergman, Mica Vanderbilt University
Regulation of gene expression in the brain Young, Walter National Institutes of Health
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University
Perturbed activity dependent plasticity mechanisms in autism Sabatini, Bernardo Harvard Medical School
Oxidative stress: Rat study Sajdel-Sulkowska, Ellen Brigham and Women's Hospital
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
Neurodevelopmental mechanisms of social behavior Levitt, Pat Vanderbilt University
Neurexin-neuroligin trans-syanptic interaction in learning and memory Kandel, Eric Columbia University
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Neocortical regionalization: Analysis of genetic and epigenetic influences Huffman, Kelly University of California, Riverside
Molecular determinants of L-type calcium channel gating Colecraft, Henry Columbia University
Models and mechanisms - 2 Sahin, Mustafa Boston Children's Hospital
Models and mechanisms - 1 Sur, Mriganka Massachusetts Institute of Technology
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine

Objective Cumulative Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.

IACC Recommended Budget: $75,000,000 over 5 years
4.5
$15,879,827
42 projects

4.S.B
$20,162,709
70 projects

4.S.B
$23,229,501
92 projects

4.S.B
$21,606,118
89 projects

4.S.B
$21,232,514
94 projects

$102,110,669
4.S.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: More than 90 projects were supported to develop animal models.

Remaining Gaps, Needs, and Opportunities: Planning Group members discussed whether the amount of investment in this area is appropriate when compared to investments in clinical trials and other later stage studies. Invited experts suggested that the current stage of scientific research in ASD requires pre-clinical research to identify targets from animal and cellular models. Similar to cancer treatment development pathways, which spanned 20-30 years, research in ASD must invest in model systems to understand the fundamental biology from which translation to the clinic can be built.  The translational validity of research in non-human animals cannot be determined until human trials are conducted, thus the need for rapid progress to clinical studies in humans is important.