|Project Title||Principal Investigator||Institution|
|Using zebrafish and chemical screening to define function of autism genes||Sive, Hazel||Whitehead Institute for Biomedical Research|
|The role of Shank3 in autism spectrum disorders||Buxbaum, Joseph||Mount Sinai School of Medicine|
|The functional neuroanatomy of memory systems in the human brain||Martin, Alex||National Institutes of Health|
|Testing the effects of cortical disconnection in non-human primates||Krauzlis, Richard||Salk Institute for Biological Studies|
|Synaptic and circuitry mechanisms of repetitive behaviors in autism||Feng, Guoping||Duke University Medical Center|
|Steroid receptors and brain sex differences||Auger, Anthony||University of Wisconsin - Madison|
|Role of Wnt signaling through Dishevelled, Dact and p120catenin in forebrain development, synaptic physiology, and mouse behavior: Exploration of a pathway with many components linked to autism spectrum disorders||Reichardt, Louis||University of California, San Francisco|
|Role of UBE3A in neocortical plasticity and function||Ehlers, Michael||Duke University|
|Role of L-type calcium channels in hippocampal neuronal network activity||Owen, Scott||Stanford University|
|Regulation of synaptogenesis by cyclin dependent kinase 5||Tsai, Li-Huei||Massachusetts Institute of Technology|
|Regulation of MET expression in autism disorder and forebrain ontogeny||Bergman, Mica||Vanderbilt University|
|Regulation of gene expression in the brain||Young, Walter||National Institutes of Health|
|Probing a monogenic form of autism from molecules to behavior||Tsien, Richard||Stanford University|
|Perturbed activity dependent plasticity mechanisms in autism||Sabatini, Bernardo||Harvard Medical School|
|Oxidative stress: Rat study||Sajdel-Sulkowska, Ellen||Brigham and Women's Hospital|
|Novel models to define the genetic basis of autism||Mills, Alea||Cold Spring Harbor Laboratory|
|Neurodevelopmental mechanisms of social behavior||Levitt, Pat||Vanderbilt University|
|Neurexin-neuroligin trans-syanptic interaction in learning and memory||Kandel, Eric||Columbia University|
|Neural and cognitive mechanisms of autism||Sur, Mriganka||Massachusetts Institute of Technology|
|Neocortical regionalization: Analysis of genetic and epigenetic influences||Huffman, Kelly||University of California, Riverside|
|Molecular determinants of L-type calcium channel gating||Colecraft, Henry||Columbia University|
|Models and mechanisms - 2||Sahin, Mustafa||Boston Children's Hospital|
|Models and mechanisms - 1||Sur, Mriganka||Massachusetts Institute of Technology|
|Mice lacking Shank postsynaptic scaffolds as an animal model of autism||Sheng, Morgan||Massachusetts Institute of Technology|
|Investigation of the role of MET kinase in autism||Dawson, Ted||Johns Hopkins University School of Medicine|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.
IACC Recommended Budget: $75,000,000 over 5 years
|4.S.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: More than 90 projects were supported to develop animal models.
Remaining Gaps, Needs, and Opportunities: Planning Group members discussed whether the amount of investment in this area is appropriate when compared to investments in clinical trials and other later stage studies. Invited experts suggested that the current stage of scientific research in ASD requires pre-clinical research to identify targets from animal and cellular models. Similar to cancer treatment development pathways, which spanned 20-30 years, research in ASD must invest in model systems to understand the fundamental biology from which translation to the clinic can be built.Â The translational validity of research in non-human animals cannot be determined until human trials are conducted, thus the need for rapid progress to clinical studies in humans is important.