Strategic Plan Objective Detail
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Question 4: Short-term Objective F  

$7,575,212.03
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SF. Launch five randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes, in each of the following groups:

Download 2010 Question 4: Short-term Objective F projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
1/3-Atomoxetine placebo and parent training in autism Handen, Benjamin University of Pittsburgh
1/3 CBT for anxiety disorders in autism: Adapting treatment for adolescents Wood, Jeffrey University of California, Los Angeles
1/3-Multisite RCT of early intervention for spoken communication in autism Kasari, Connie University of California, Los Angeles
2/3-Atomoxetine placebo and parent training in autism Aman, Michael Ohio State University
2/3 CBT for anxiety disorders in autism: Adapting treatment for adolescents Storch, Eric University of South Florida
2/3-Multisite RCT of early intervention for spoken communication in autism Smith, Tristram University of Rochester
3/3-Atomoxetine placebo and parent training in autism Smith, Tristram University of Rochester
3/3 CBT for anxiety disorders in autism: Adapting treatment for adolescents Ehrenreich-May, Jill University of Miami
3/3-Multisite RCT of early Intervention for spoken communication in autism Landa, Rebecca Kennedy Krieger Institute
ACE Center: Risk and protective factors in the development of associated symptoms in autism Estes, Annette University of Washington
ACE Network: Early pharmacotherapy guided by biomarkers in autism Chugani, Diane Wayne State University
A randomized clinical trial of cognitive enhancement therapy for adults with autism spectrum disorders Minshew, Nancy University of Pittsburgh
A sibling mediated imitation intervention for young children with autism Meyer, Katherine Michigan State University
Biomarkers in Autism of Aripiprazole and Risperidone Treatment (BAART) Devane, C. Lindsay Medical University of South Carolina
Early intervention for children screened positive for autism by the First Year Inventory Baranek, Grace; Watson, Linda; Reznick, Steven; Crais, Elisabeth University of North Carolina at Chapel Hill
Enhancing inter-subjectivity in infants at high risk for autism Bryson, Susan; Brian, Jessica; Smith, Isabel; Zwaigenbaum, Lonnie; Roberts, Wendy IWK Health Centre/Dalhousie University; University of Toronto; University of Alberta; The Hospital for Sick Children
Enhancing understanding and use of conversational rules in school-aged speakers with autism spectrum disorders Austin, Sarita Yale University
Evaluating behavioral and neural effects of social skills intervention for school-age children with autism spectrum disorders Wang, A. Ting; Soorya, Latha Mount Sinai School of Medicine
Evidence-based cognitive rehabilitation to improve functional outcomes for young adults with autism spectrum disorders Minshew, Nancy University of Pittsburgh
HCC: Collaborative research: Social-emotional technologies for autism spectrum disorders Goodwin, Matthew The Groden Center, Inc.
HCC: Collaborative research: Social-emotional technologies for autism spectrum disorders Picard, Rosalind Massachusetts Institute of Technology
Improving synchronization and functional connectivity in autism spectrum disorders through plasticity-induced rehabilitation training Pineda, Jaime University of California, San Diego
Integrated play groups: Promoting social communication and symbolic play with peers across settings in children with autism Wolfberg, Pamela San Francisco State University
Neural and behavioral outcomes of social skills groups in children with ASD Wang, A. Ting; Soorya, Latha Mount Sinai School of Medicine
Neurocognitive markers of response to treatment in autism Young, Gregory University of California, Davis

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups:
  • Five trials in infants and toddlers by 2013.

    IACC Recommended Budget: $30,000,000 over 5 years (revised in 2010)
  • Three trials in school-aged children and/or adolescents by 2013.

    IACC Recommended Budget: $18,000,000 over 5 years (revised in 2010)
  • Three trials in adults by 2014.

    IACC Recommended Budget: $18,000,000 over 5 years

Total IACC Recommended Budget: $66,000,000 over 5 years

4.3 & 4.4
$12,109,516
16 projects & 30 projects

4.S.F
$9,791,270
42 projects

4.S.F
$7,575,212
30 projects

4.S.F
$5,445,599
23 projects


4.S.F
$6,255,438
21 projects


$41,177,035
4.S.F. Funding: The recommended budget was partially met.

Progress: The investment in projects under this objective is making good progress toward the recommended amount, with more than 20 projects funded in 2011 and 2012.

Remaining Gaps, Needs, and Opportunities: Current projects in this area are restricted to small pilot studies, which are essential to establishing a foundation prior to expansion to larger scale work. Thus, increased investment in this area is important. It should be noted that most RCTs in the future will incorporate some aspect of biological signatures (thus potentially presenting a challenge to future coding of projects).