Strategic Plan Objective Detail
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Question 2: Short-term Objective A  

$4,972,407.28
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Download 2010 Question 2: Short-term Objective A projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
A mitochondrial etiology of autism Wallace, Douglas Children's Hospital of Philadelphia
Project 2: Immunological susceptibility of autism Van de Water, Judy University of California, Davis
The effect of mercury and neuropeptide triggers on human mast cell release of neurotoxic molecules Theohardies, Theoharis Tufts University
Does mercury and neurotension induce mitochondrial DNA release from human mast cells and contribute to auto-immunity in ASD? Theohardies, Theoharis Tufts University
Mechanisms of mitochondrial dysfunction in autism Shoffner, John Georgia State University
Environmentally induced oxidative stress and altered local brain thyroid horomone metabolism: relevance to autism? Sajdel-Sulkowski, Elizabeth Harvard Medical School; Brigham and Women's Hospital
A primate model of gut, immune, and CNS response to childhood vaccines Sackett, Gene University of Washington
EFRI- BSBA: Novel microsystems for manipulation and analysis of immune cells Revzin, Alexander University of California, Davis
Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance Rall, Glenn The Fox Chase Cancer Center
Influence of maternal cytokines on activation of the innate immune system as a factor in the development of autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Influence of the maternal immune response on the development of autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Gene-environment interactions in the pathogenesis of autism-like neurodevelopmental damage: A mouse model Pletnikov, Mikhail Johns Hopkins University School of Medicine
A non-human primate autism model based on maternal infection Patterson, Paul California Institute of Technology
A non-human primate autism model based on maternal immune activation Patterson, Paul University of California, Davis
Neurological diseases due to inborn errors of metabolism Pascual, Juan University of Texas Southwestern Medical Center
Maternal infection and autism: Impact of placental sufficiency and maternal inflammatory responses on fetal brain development Palmer, Theo Stanford University
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development Noble, Mark University of Rochester
Influence of oxidative stress on transcription and alternative splicing of methionine synthase in autism Muratore, Christina Northeastern University
Prostaglandins and cerebellum development McCarthy, Margaret University of Maryland, Baltimore
Maternal immune activation, cytokines, and the pathogenesis of autism McAllister, A. Kimberley University of California, Davis
Immune molecules and cortical synaptogenesis: Possible implications for the pathogenesis of autism McAllister, A. Kimberley University of California, Davis
Regulation of inflammatory Th17 cells in autism spectrum disorder Littman, Dan New York University School of Medicine
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development James, Sandra Arkansas Children's Hospital Research Institute
How does IL-6 mediate the development of autism-related behaviors? Hsiao, Elaine California Institute of Technology