Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

$13,162,905.00
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Baylor College of Medicine
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Cold Spring Harbor Laboratory
The role of the autism-associated gene tuberous sclerosis complex 2 (TSC2) in presynaptic development Williams, Megan University of California, San Diego
Regulation of synapse elimination by FMRP Wilkerson, Julia University of Texas Southwestern Medical Center
Gene silencing in fragile X syndrome Usdin, Karen National Institutes of Health
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University
TrkB agonist(s), a potential therapy for autism spectrum disorders Sun, Yi University of California, Los Angeles
Aberrant synaptic form and function due to TSC-mTOR-related mutation in autism spectrum disorders Sulzer, David Columbia University
Aberrant synaptic function caused by TSC mutation in autism Sulzer, David Columbia University
Investigation of postnatal drug intervention's potential in rescuing the symptoms of fragile X syndrome in adult mice Sidorov, Michael Massachusetts Institute of Technology
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Dana-Farber Cancer Institute
Sex differences in early brain development; Brain development in Turner syndrome Santelli, Rebecca University of North Carolina at Chapel Hill
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Children's Hospital Boston
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Johns Hopkins University
Proteomics in drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence University of Tennessee Health Science Center
Augmentation of the cholinergic system in fragile X syndrome: A double-blind placebo study Reiss, Allan Stanford University
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas University of Alabama at Birmingham
Angelman syndrome (AS) Percy, Alan University of Alabama at Birmingham
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis University of Texas Southwestern Medical Center
L-type calcium channel regulation of neuronal differentiation Panagiotakos, Georgia Stanford University
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Washington University in St. Louis
Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome Lin, Michael Stanford University
The role of MeCP2 in Rett syndrome LaSalle, Janine University of California, Davis
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony The George Washington University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony University of North Carolina at Chapel Hill