|Project Title||Principal Investigator||Institution|
|Cellular and genetic correlates of increased head size in autism spectrum disorder||Vaccarino, Flora||Yale University|
|Rapid characterization of balanced genomic rearrangements contributing to autism||Talkowski, Michael||Massachusetts General Hospital|
|A systematic test of the relation of ASD heterogeneity to synaptic function||Sudhof, Thomas||Stanford University|
|Neuroligin function in vivo: Implications for autism and mental retardation||Powell, Craig||University of Texas Southwestern Medical Center|
|Neural circuitry of social cognition in the broad autism phenotype||Piven, Joseph||University of North Carolina at Chapel Hill|
|Longitudinal neurogenetics of atypical social brain development in autism||Pelphrey, Kevin||Yale University|
|Language processing in children with 22q11 deletion syndrome and autism||Ousley, Opal||Emory University|
|Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD||Monk, Christopher||University of Michigan|
|Autism: The neural substrates of language in siblings||Lindgren, Kristen||Boston University Medical Campus|
|fMRI evidence of genetic influence on rigidity in ASD||Lee, Jillian||University of Michigan|
|Autism: Neuropeptide hormones and potential pathway genes||Jacob, Suma||University of Illinois at Chicago|
|Multimodal neuroimaging of white matter in autism||Herbert, Martha||Massachusetts General Hospital|
|A neuroimaging study of twin pairs with autism||Hardan, Antonio||Stanford University|
|Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells||Hallmayer, Joachim||Stanford University|
|Patient iPS cells with copy number variations to model neuropsychiatric disorders||Ellis, James||The Hospital for Sick Children|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models||Dulawa, Stephanie||University of Chicago|
|Using induced pluripotent stem cells to identify cellular phenotypes of autism||Dolmetsch, Ricardo||Stanford University|
|Self-injurious behavior: An animal model of an autism endophenotype||Devine, Darragh||University of Florida|
|Autism-specific mutation in DACT1: Impact on brain development in a mouse model||Cheyette, Benjamin||University of California, San Francisco|
|The brain genomics superstruct project||Buckner, Randy L.||President & Fellows of Harvard College|
|Regulation of MET expression in autism disorder and forebrain ontogeny||Bergman, Mica||Vanderbilt University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.
IACC Recommended Budget: $22,600,000 over 5 years
|2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.
Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.