|Project Title||Principal Investigator||Institution|
|Identifying autism susceptibility genes by high-throughput chip resequencing||Zwick, Michael||Emory University|
|Analysis of candidate genes derived from a protein interaction network in SSC samples||Zoghbi, Huda||Baylor College of Medicine|
|Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy||Yang, Xiangdong||University of California, Los Angeles|
|ACE Center: Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|Genetic basis of autism||Wigler, Michael||Cold Spring Harbor Laboratory|
|Deep sequencing of autism candidate genes in 2000 families from the Simons Simplex Collection||Wigler, Michael||Cold Spring Harbor Laboratory|
|Comprehensive genetic variation detection to assess the role of the X chromosome in autism||Warren, Stephen||Emory University|
|Understanding glutamate signaling defects in autism spectrum disorders||Wang, Tao||Johns Hopkins University|
|Simons Simplex Collection Site||Walsh, Christopher||Children's Hospital Boston|
|Recessive genes for autism and mental retardation||Walsh, Christopher||Beth Israel Deaconess Medical Center|
|Finding autism genes by genomic copy number analysis||Walsh, Christopher||Children's Hospital Boston|
|Identification and functional assessment of autism susceptibility genes||Vieland, Veronica||The Research Institute at Nationwide Children's Hospital|
|Role of micro-RNAs in ASD affected circuit formation and function||Ullian, Erik||University of California, San Francisco|
|Potential role of non-coding RNAs in autism||Talebizadeh, Zohreh||Children's Mercy Hospitals And Clinics|
|Simons Simplex Collection Site||Sutcliffe, James||Vanderbilt University|
|Unraveling the genetic etiology of autism||Sutcliffe, James||Vanderbilt University|
|Isolation of autism susceptibility genes||Stefansson, Kari||deCODE Genetics, Inc.|
|A genome-wide search for autism genes in the Simons Simplex Collection||State, Matthew||Yale University|
|Autism Genome Project (AGP)||Staff Member||Autism Speaks (AS)|
|Autism Genetic Resource Exchange (AGRE)||Staff Member||Autism Speaks (AS)|
|Determining the genetic basis of autism by high-resolution analysis of copy number||Sebat, Jonathan||Cold Spring Harbor Laboratory|
|The impact of autism specific genomic variations on microRNA gene expression profile||Scherer, Stephen||The Hospital for Sick Children|
|Investigation of genes involved in synaptic plasticity in Iranian families with ASD||Santangelo, Susan||Massachusetts General Hospital|
|Role of TSC/mTOR signaling pathway in autism and autism spectrum disorders||Ramesh, Vijaya||Massachusetts General Hospital|
|Research Center for the Study of Gene Structure and Function (supplement)||Raab, Jennifer||Hunter College|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.