|Project Title||Principal Investigator||Institution|
|Regulation of gene expression in the brain||Young, Walter||National Institutes of Health|
|Probing a monogenic form of autism from molecules to behavior||Tsien, Richard||Stanford University|
|Regulation of synaptogenesis by cyclin dependent kinase 5||Tsai, Li-Huei||Massachusetts Institute of Technology|
|Cognitive mechanisms of serially organized behavior||Terrace, Herbert||Columbia University|
|Models and mechanisms - 1||Sur, Mriganka||Massachusetts Institute of Technology|
|Neural and cognitive mechanisms of autism||Sur, Mriganka||Massachusetts Institute of Technology|
|Aberrant synaptic function due to TSC mutation in autism||Sulzer, David||Columbia University Medical Center|
|Function and dysfunction of neuroligins||Sudhof, Thomas||Stanford University|
|Using zebrafish and chemical screening to define function of autism genes||Sive, Hazel||Whitehead Institute for Biomedical Research|
|Mice lacking Shank postsynaptic scaffolds as an animal model of autism||Sheng, Morgan||Massachusetts Institute of Technology|
|Genetic analyses of ARX homeobox gene function in neurodevelopmental disorders||Sengupta, Piali||Brandeis University|
|Connectopathic analysis of autism||Sanes, Joshua||Harvard University|
|Oxidative stress: Rat study||Sajdel-Sulkowska, Ellen||Brigham and Women's Hospital|
|Models and mechanisms - 2||Sahin, Mustafa||Boston Children's Hospital|
|Perturbed activity dependent plasticity mechanisms in autism||Sabatini, Bernardo||Harvard Medical School|
|Role of Wnt signaling through Dishevelled, Dact and p120catenin in forebrain development, synaptic physiology, and mouse behavior: Exploration of a pathway with many components linked to autism spectrum disorders||Reichardt, Louis||University of California, San Francisco|
|A non-human primate autism model based on maternal infection||Patterson, Paul||California Institute of Technology|
|Dysregulation of p13/AKT in mouse models for social interaction deficits and for ASD with macrocephaly||Parada, Luis||University of Texas Southwestern Medical Center|
|Role of L-type calcium channels in hippocampal neuronal network activity||Owen, Scott||Stanford University|
|Novel models to define the genetic basis of autism||Mills, Alea||Cold Spring Harbor Laboratory|
|A mouse knock-in model for Engrailed 2 autism susceptibility||Millonig, James||University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School|
|The functional neuroanatomy of memory systems in the human brain||Martin, Alex||National Institutes of Health|
|Neurodevelopmental mechanisms of social behavior||Levitt, Pat||Vanderbilt University|
|Testing the effects of cortical disconnection in non-human primates||Krauzlis, Richard||Salk Institute for Biological Studies|
|Neurexin-neuroligin trans-syanptic interaction in learning and memory||Kandel, Eric||Columbia University|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.
IACC Recommended Budget: $75,000,000 over 5 years
|4.S.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: More than 90 projects were supported to develop animal models.
Remaining Gaps, Needs, and Opportunities: Planning Group members discussed whether the amount of investment in this area is appropriate when compared to investments in clinical trials and other later stage studies. Invited experts suggested that the current stage of scientific research in ASD requires pre-clinical research to identify targets from animal and cellular models. Similar to cancer treatment development pathways, which spanned 20-30 years, research in ASD must invest in model systems to understand the fundamental biology from which translation to the clinic can be built.Â The translational validity of research in non-human animals cannot be determined until human trials are conducted, thus the need for rapid progress to clinical studies in humans is important.