|Project Title||Principal Investigator||Institution|
|A prospective multi-system evaluation of infants at risk for autism||Bauman, Margaret||Massachusetts General Hospital|
|Video game environments for the integrative study of perception, attention and social cognition in autism and autism sibs||Belmonte, Matthew||Cornell University|
|Imitation in autism||Bolton, Patrick||King's College London|
|Neural mechanisms underlying obsessive compulsiveness in ASD||Carrasco, Melisa||University of Michigan|
|Development of face processing in infants with autism spectrum disorders||Chawarska, Katarzyna||Yale University|
|Ethnicity and the elucidation of autism endophenotypes||Constantino, John||Washington University in St. Louis|
|ACE Center: Early detection and intervention in infants at risk for autism||Dawson, Geraldine||University of Washington|
|Collaborative research: Computational behavioral science: Modeling, analysis, and visualization of social and communicative behavior||Dey, Anind||Carnegie Mellon University|
|Translational developmental neuroscience of autism||Di Martino, Adriana||New York University School of Medicine|
|Extraction of functional subnetworks in autism using multimodal MRI||Duncan, James; Syaib, Lawrence; Pelphrey, Kevin||Yale University|
|Collaborative research: Computational behavioral science: Modeling, analysis, and visualization of social and communicative behavior||Forsyth, David||University of Illinois at Urbana-Champaign|
|A prospective multi-system evaluation of infants at risk for autism||Herbert, Martha||Massachusetts General Hospital|
|Multiple social tasks and social adjustment||Kang, Sun-Mee||California State University, Northridge|
|Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for idiopathic ASD||Kaufmann, Walter||Kennedy Krieger Institute|
|Perception of social and physical contingencies in infants with ASD||Klin, Ami||Yale University|
|Performance indices of social disability in toddlers with autism (supplement)||Klin, Ami||Yale University|
|ACE Center: Eye-tracking studies of social engagement||Klin, Ami||Yale University|
|Performance indices of social disability in toddlers with autism||Klin, Ami||Yale University|
|Child-initiated communicative interactions and autism intervention||Koegel, Robert||University of California, Santa Barbara|
|Child-initiated communicative interactions and autism intervention (supplement)||Koegel, Robert||University of California, Santa Barbara|
|Autism: Social and communication predictors in siblings||Landa, Rebecca||Kennedy Krieger Institute|
|Neuroimaging & symptom domains in autism||Levitt, Jennifer||University of California, Los Angeles|
|Growth and maturation in children with autism||Louis, Germaine||National Institutes of Health|
|Perceptual factors affecting social attention in autism spectrum disorders||Macari, Suzanne||Yale University|
|Using a direct observation assessment battery to assess outcome of early intensive behavioral intervention for children with autism||MacDonald, Rebecca||New England Center for Children|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015.
IACC Recommended Budget: $71,100,000 over 5 years
|1.L.B. Funding: The recommended budget was partially met.
Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.
Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.