Strategic Plan Objective Detail
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Question 2: Short-term Objective B  

$1,096,678.00
Fiscal Year: 2010

Yellow dot: Objective has some degree of funding, but less than the recommended amount.2SB. Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years.

Download 2010 Question 2: Short-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Steroid receptors and brain sex differences Auger, Anthony University of Wisconsin - Madison
The neural basis of sexually dimorphic brain function De Vries, Geert University of Massachusetts Amherst
A sex-specific dissection of autism genetics Weiss, Lauren University of California, San Francisco
A sex-specific dissection of autism genetics Weiss, Lauren University of California, San Francisco
Investigation of sex differences associated with autism candidate gene, CYFIP1 Werling, Donna University of California, Los Angeles

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011.

IACC Recommended Budget: $8,900,000 over 5 years
2.3
$0
0 projects

2.S.B
$1,370,107
5 projects

2.S.B
$1,096,678
5 projects

2.S.B
$150,000
1 project

2.S.B
$3,239,998
5 projects

$5,856,783
2.S.B. Funding: The recommended budget was partially met.

Progress: More than the minimum three studies recommended were launched, but further work is needed in this area. Studies have found that females with ASD often have a higher burden of ASD genetic risk mutations than males, suggesting a gender-associated protective effect in females. Research on factors protecting females from developing ASD symptoms even when challenged with genetic mutations that lead to ASD in boys may help to identify approaches to prevent development of ASD symptoms in both genders.

Remaining Gaps, Needs and Opportunities: Studies of protective and compensatory effects in females and differential response to treatment based on gender are promising areas that could help with future prevention and effective, personalized treatment efforts. Beyond genetic differences, it is important to determine whether other biological features, such as differences in neuropathology, are found in the two sexes.