|Project Title||Principal Investigator||Institution|
|Simons Variation in Individuals Project (VIP) Site||Bernier, Raphael||University of Washington|
|Neural and phenotypic correlates of autism risk genes||Bookheimer, Susan||University of California, Los Angeles|
|Behavioral and genetic biomarker development for autism and related disorders||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|The brain genomics superstruct project||Buckner, Randy||President & Fellows of Harvard College|
|Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift||Chung, Wendy||Columbia University|
|Autistic traits: Life course & genetic structure||Constantino, John||Washington University|
|ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes||Cook, Edwin||University of Illinois at Chicago|
|The genetic basis of mid-hindbrain malformations||Dobyns, William||Seattle Children's Hospital|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models||Dulawa, Stephanie||University of Chicago|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement)||Dulawa, Stephanie||University of Chicago|
|ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition||Geschwind, Daniel||University of California, Los Angeles|
|Simons Variation in Individual Project (Simons VIP) Core Leader Gift||Hanson, Ellen||Children's Hospital Boston|
|A neuroimaging study of twin pairs with autism||Hardan, Antonio||Stanford University|
|Autism: Neuropeptide hormones and potential pathway genes (supplement)||Jacob, Suma||University of Illinois at Chicago|
|Autism: Neuropeptide hormones and potential pathway genes||Jacob, Suma||University of Illinois at Chicago|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|fMRI evidence of genetic influence on rigidity in ASD||Lee, Jillian||University of Michigan|
|Simons Variation in Individuals Project (Simons VIP)||Lese Martin, Christa||Emory University|
|Autism: The neural substrates of language in siblings||Lindgren, Kristen||Boston University Medical Campus|
|A multigenerational longitudinal study of language development: Insight from autism||Losh, Molly||University of North Carolina at Chapel Hill|
|A multigenerational longitudinal study of language development: Insight from autism||Losh, Molly||Northwestern University|
|A family-genetic study of language in autism||Losh, Molly||Northwestern University|
|A family-genetic study of language in autism||Losh, Molly||University of North Carolina at Chapel Hill|
|Neural correlates of restricted, repetitive behaviors in autism spectrum disorders||Manoach, Dara||Massachusetts General Hospital|
|An investigation of the overlap of autism and fragile X syndrome||Martin, Gary||University of North Carolina at Chapel Hill|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.
IACC Recommended Budget: $22,600,000 over 5 years
|2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.
Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.