Strategic Plan Objective Detail
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Question 2: Short-term Objective G  

$9,149,672.07
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Download 2010 Question 2: Short-term Objective G projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Simons Variation in Individuals Project (VIP) Site Bernier, Raphael University of Washington
Neural and phenotypic correlates of autism risk genes Bookheimer, Susan University of California, Los Angeles
Behavioral and genetic biomarker development for autism and related disorders Brzustowicz, Linda Rutgers, The State University of New Jersey - New Brunswick
The brain genomics superstruct project Buckner, Randy President & Fellows of Harvard College
Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift Chung, Wendy Columbia University
Autistic traits: Life course & genetic structure Constantino, John Washington University
ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes Cook, Edwin University of Illinois at Chicago
The genetic basis of mid-hindbrain malformations Dobyns, William Seattle Children's Hospital
Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models Dulawa, Stephanie University of Chicago
Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement) Dulawa, Stephanie University of Chicago
ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition Geschwind, Daniel University of California, Los Angeles
Simons Variation in Individual Project (Simons VIP) Core Leader Gift Hanson, Ellen Children's Hospital Boston
A neuroimaging study of twin pairs with autism Hardan, Antonio Stanford University
Autism: Neuropeptide hormones and potential pathway genes (supplement) Jacob, Suma University of Illinois at Chicago
Autism: Neuropeptide hormones and potential pathway genes Jacob, Suma University of Illinois at Chicago
Genetic dissection of restricted repetitive behavior (RRB) Kim, Soo-Jeong University of Florida
fMRI evidence of genetic influence on rigidity in ASD Lee, Jillian University of Michigan
Simons Variation in Individuals Project (Simons VIP) Lese Martin, Christa Emory University
Autism: The neural substrates of language in siblings Lindgren, Kristen Boston University Medical Campus
A family-genetic study of language in autism Losh, Molly University of North Carolina at Chapel Hill
A family-genetic study of language in autism Losh, Molly Northwestern University
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly University of North Carolina at Chapel Hill
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Northwestern University
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Manoach, Dara Massachusetts General Hospital
An investigation of the overlap of autism and fragile X syndrome Martin, Gary University of North Carolina at Chapel Hill

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.

IACC Recommended Budget: $22,600,000 over 5 years
N/A

2.S.G
$5,903,875
21 projects

2.S.G
$9,149,672
39 projects

2.S.G
$11,105,408
45 projects

2.S.G
$15,618,073
44 projects

$41,777,028
2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.

Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.