Strategic Plan Objective Detail
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Question 3: Short-term Objective A  

$13,926,663.00
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Download 2009 Question 3: Short-term Objective A projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Neural and phenotypic correlates of autism risk genes Bookheimer, Susan University of California, Los Angeles
3/5-Elucidating the genetic architecture of autism by deep genomic sequencing Buxbaum, Joseph Mount Sinai School of Medicine
2/5-Elucidating the genetic architecture of autism by deep genomic sequencing Daly, Mark Broad Institue, Inc.
1/5-Elucidating the genetic architecture of autism by deep genomic sequencing Gibbs, Richard Baylor College of Medicine
A systems biology approach to unravel the underlying functional modules of ASD Iakoucheva, Lilia University of California, San Diego
Genetic study of restricted repetitive behavior in autism spectrum disorders Kim, Soo-Jeong University of Florida
4/5-Elucidating the genetic architecture of autism by deep genomic sequencing Schellenberg, Gerard University of Pennsylvania
Genomic profiling and functional mutation analysis in autism spectrum disorders State, Matthew Yale University
5/5-Elucidating the genetic architecture of autism by deep genomic sequencing Sutcliffe, James Vanderbilt University
Biological correlates of altered brain growth in autism Vaccarino, Flora Yale University
Human autism genetics and activity-dependent gene activation Walsh, Christopher Children's Hospital Boston

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals who share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features.

IACC Recommended Budget: $43,700,000 over 4 years
3.2
$4,065,392
14 projects

3.S.A
$13,926,663
11 projects

3.S.A
$16,688,932
14 projects

3.S.A
$2,207,214
7 projects

3.S.A
$1,699,432
6 projects

$38,587,633
3.S.A. Funding: The recommended budget was partially met, and is approaching the recommended budget.

Progress: Progress has been made on this objective through the funding of several GWAS and sequencing projects. The current number of 6,000 GWAS subjects falls short of the goal of 20,000, but the number of whole exome sequences far exceeds 1,200, and could also reach 6,000 in the next year. Whole exome sequencing has identified 7-10 candidate genes, and promises to move closer to the goal of 50 in the future. Progress is being made in CNV studies. Overall, the work is on target.

Remaining Gaps, Needs, and Opportunities: More subtyping and genotype-phenotype work outside of syndromic forms of autism, as well as natural history studies, are needed.