Strategic Plan Objective Detail
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Question 3: Short-term Objective A  

$16,688,932.00
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Download 2010 Question 3: Short-term Objective A projects (EXCEL)
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Project Title Principal Investigator Institution
Advanced parental age and autism: The role of aneuploidy and uniparental disomy in ASD pathogenesis Berko, Esther Albert Einstein College of Medicine of Yeshiva University
3/5-Elucidating the genetic architecture of autism by deep genomic sequencing Buxbaum, Joseph Mount Sinai School of Medicine
2/5-Elucidating the genetic architecture of autism by deep genomic sequencing Daly, Mark Broad Institute
1/5-Elucidating the genetic architecture of autism by deep genomic sequencing Gibbs, Richard Baylor College of Medicine
A molecular genetic study of autism and related phenotypes in extended pedigrees (supplement) Piven, Joseph University of North Carolina at Chapel Hill
A molecular genetic study of autism and related phenotypes in extended pedigrees Piven, Joseph University of North Carolina at Chapel Hill
4/5-Elucidating the genetic architecture of autism by deep genomic sequencing Schellenberg, Gerard University of Pennsylvania
Genomic profiling and functional mutation analysis in autism spectrum disorders State, Matthew; Giraldez, Antonio Yale University
5/5-Elucidating the genetic architecture of autism by deep genomic sequencing Sutcliffe, James Vanderbilt University
Biological correlates of altered brain growth in autism Vaccarino, Flora; Gerstein, Mark; Grigorenko, Elena; Weissman, Sherman Yale University
Human autism genetics and activity dependent gene activation Walsh, Christopher Children's Hospital Boston
Finding autism genes by genomic copy number analysis Walsh, Christopher Children's Hospital Boston
Dissecting epistasis and pleiotropy in autism towards personalized medicine Weiss, Lauren University of California, San Francisco
Deep sequencing of autism candidate genes in 2000 families from the Simons Simplex Collection Wigler, Michael; McCombie, William Cold Spring Harbor Laboratory