|Project Title||Principal Investigator||Institution|
|Brain glutamate concentrations in autistic adolescents by MRS||Anagnostou, Athanasius||Mount Sinai School of Medicine|
|Vaccination with regression study||Davis, Robert||Kaiser Permanente Georgia|
|Psychosis and autoimmune diseases in Denmark||Eaton, William||Johns Hopkins University|
|Epidemiologic studies of reproductive and developmental outcomes – Denmark||Kjaergaard, Soren||Aarhus University|
|Interactions of environment and molecular pathways on brain overgrowth in autism: Maternal inflammation and the PI3/AKT pathway||Lebelle, Janel||University of California, Los Angeles|
|Genome-wide association study of autism characterized by developmental regression||Molloy, Cynthia||Cincinnati Children's Hospital Medical Center|
|Vulnerability phenotypes and susceptibility to environmental toxicants: From organism to mechanism||Noble, Mark||University of Rochester|
|Influence of the maternal immune response on the development of autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Influence of maternal cytokines on activation of the innate immune system as a factor in the development of autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Etiology of autism risk involving MET gene and the environment||Van de Water, Judy||University of California, Davis|
|Immunobiology in autism||Van de Water, Judy||University of California, Davis|
|Evaluation of the immune and physiologic response in children with autism following immune challenge||Van de Water, Judy||University of California, Davis|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support at least two studies to determine if there are subpopulations that are more susceptible to environmental exposures (e.g., immune challenges related to infections, vaccinations, or underlying autoimmune problems) by 2012.
IACC Recommended Budget: $8,000,000 over 2 years
|3.S.E. Funding: The recommended budget was partially met.
Progress: Several projects were funded in this area, going beyond the minimum recommended by the committee, but the projects have been smaller than what was expected. However, even with smaller studies, a large amount of data has been collected relating to immunological conditions in children and mothers.
Remaining Gaps, Needs, and Opportunities: More work is needed to analyze and interpret available data.