Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

$23,229,501.04
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Neurobiological mechanism of 15q11-13 duplication autism spectrum disorder Anderson, Matthew Beth Israel Deaconess Medical Center
The role of SHANK3 in the etiology of autism spectrum disorder Bangash, M. Ali Johns Hopkins University
Neurobiology of mouse models for human chr 16p11.2 microdeletion and fragile X Bear, Mark Massachusetts Institute of Technology
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Massachusetts Institute of Technology
Transgenic mouse model to address heterogeneity in autism spectrum disorders Blakely, Randy Vanderbilt University
The genetic control of social behavior in the mouse Blanchard, Robert University of Hawai'i at Manoa
Neurobiology of sociability in a mouse model system relevant to autism Brodkin, Edward University of Pennsylvania
Identifying genetic modifiers of rett syndrome in the mouse Buchovecky, Christine Baylor College of Medicine
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Mount Sinai School of Medicine
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie New York University
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Stanford University
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Stanford University
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph The Rockefeller University
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Duke University
Patient iPS cells with copy number variations to model neuropsychiatric disorders Ellis, James The Hospital for Sick Children
Dissecting the circuitry basis of autistic-like behaviors in mice Feng, Guoping Massachusetts Institute of Technology
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Massachusetts Institute of Technology
Functional genomic dissection of language-related disorders Fisher, Simon University of Oxford
Deriving neuroprogenitor cells from peripheral blood of individuals with autism Fujinami, Robert University of Utah
Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes Garner, Craig Stanford University
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Columbia University
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim; Dolmetsch, Ricardo Stanford University