Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

$23,229,501.04
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Analysis of cortical circuits related to ASD gene candidates Zador, Anthony Cold Spring Harbor Laboratory
Regulation of gene expression in the brain Young, Walter National Institutes of Health
Vasopressin receptors and social attachment Young, Larry Emory University
Neural mechanisms of social cognition and bonding Young, Larry Emory University
Central vasopressin receptors and affiliation Young, Larry Emory University
Central vasopressin receptors and affiliation Young, Larry Emory University
Neural mechanisms of social cognition and bonding Young, Larry Emory University
Genomic resources for identifying genes regulating social behavior Young, Larry Emory University
Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy Yang, Xiangdong University of California, Los Angeles
Dynamic regulation of Shank3 and ASD Worley, Paul Johns Hopkins University
Cntnap2 in a behavioral model of autism White, Stephanie University of California, Los Angeles
Murine genetic models of autism Veenstra-Vanderweele, Jeremy Vanderbilt University
Mouse genetic model of a dysregulated serotonin transporter variant associated with autism Veenstra-Vanderweele, Jeremy Vanderbilt University
Integrated approach to the neurobiology of autism spectrum disorders Vaccarino, Flora Yale University
Cellular and genetic correlates of increased head size in autism spectrum disorder Vaccarino, Flora Yale University
Characterization of the transcriptome in an emerging model for social behavior Thomas, James Emory University
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Function and dysfunction of neuroligins Sudhof, Thomas Stanford University
Identifying impairments in synaptic connectivity in mouse models of ASD Speed, Haley University of Texas Southwestern Medical Center
Characterization of autism susceptibility genes on chromosome 15q11-13 Smith, Stephen Beth Israel Deaconess Medical Center
Using zebrafish and chemical screening to define function of autism genes Sive, Hazel Whitehead Institute for Biomedical Research
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Dissecting the neural control of social attachment Shah, Nirao University of California, San Francisco
Methods for production of ICSI and SCNT derived macaque stem cells Schatten, Gerald Southwest Foundation For Biomedical Research
Optimization of methods for production of both ICSI- and SCNT derived baboon embryonic stem cells Schatten, Gerald Southwest Foundation For Biomedical Research