Strategic Plan Objective Detail
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Question 3: Long-term Objective B  

$49,905,587.13
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2009 Question 3: Long-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Autism Genetic Resource Exchange (AGRE) Staff Member Autism Speaks (AS)
Autism Genome Project (AGP) Staff Member Autism Speaks (AS)
The role of the Rett gene, chromosone 15Q11-Q13, other genes, and epigenetics Beaudet, Arthur Baylor College of Medicine
Analysis of candidate genes derived from a protein interaction network in SSC samples Zoghbi, Huda Baylor College of Medicine
Studies of postmortem brain searching for epigenetic defects causing autism Beaudet, Arthur Baylor College of Medicine
Simons Simplex Collection Site Kochel, Robin Baylor College of Medicine
Recessive genes for autism and mental retardation Walsh, Christopher Beth Israel Deaconess Medical Center
Genetic investigation of cognitive development in autistic spectrum disorders Morrow, Eric Brown University
Autism and the insula: Genomic and neural circuits Allman, John California Institute of Technology
Gene expression profiling of autism spectrum disorders Collins, Christin Children's Hospital Boston
RNA expression patterns in autism Kunkel, Louis Children's Hospital Boston
Uncovering genetic mechanisms of ASD Kunkel, Louis Children's Hospital Boston
Finding autism genes by genomic copy number analysis Walsh, Christopher Children's Hospital Boston
Simons Simplex Collection Site Walsh, Christopher Children's Hospital Boston
Potential role of non-coding RNAs in autism Talebizadeh, Zohreh Children's Mercy Hospitals And Clinics
Deep sequencing of autism candidate genes in 2000 families from the Simons Simplex Collection Wigler, Michael Cold Spring Harbor Laboratory
Determining the genetic basis of autism by high-resolution analysis of copy number Sebat, Jonathan Cold Spring Harbor Laboratory
Genetic basis of autism Wigler, Michael Cold Spring Harbor Laboratory
Core--Genomics/Bioinformatics--Alzheimer's disease and autism Gilliam, Thomas Columbia University
Simons Simplex Collection Site Peterson, Bradley Columbia University
Isolation of autism susceptibility genes Stefansson, Kari deCODE Genetics, Inc.
Genetic studies in autism on chromosome 7 (supplement) Pericak-Vance, Margaret Duke University
Molecular Analysis Core (supplement) Pericak-Vance, Margaret Duke University
Neurogenetics of candidate systems in autism (supplement) Haines, Jonathan Duke University
Clinical and Bioinformatics Core (supplement) Pericak-Vance, Margaret Duke University

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.