Strategic Plan Objective Detail
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Question 3: Long-term Objective B  

$34,432,884.28
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2010 Question 3: Long-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Autism Genome Project (AGP) Staff Member Autism Speaks (AS)
Simons Simplex Collection Treadwell-Deering, Diane Baylor College of Medicine
Analysis of candidate genes derived from a protein interaction network in SSC samples Zoghbi, Huda Baylor College of Medicine
Simons Simplex Collection Site Kochel, Robin Baylor College of Medicine
Recessive genes for autism and mental retardation Walsh, Christopher Beth Israel Deaconess Medical Center
Genetic investigation of cognitive development in autistic spectrum disorders Morrow, Eric Brown University
Gene expression profiling of autism spectrum disorders Collins, Christin Children's Hospital Boston
Finding recessive genes for autism spectrum disorders Walsh, Christopher Children's Hospital Boston
Simons Simplex Collection Site Walsh, Christopher Children's Hospital Boston
RNA expression patterns in autism Kunkel, Louis Children's Hospital Boston
Uncovering genetic mechanisms of ASD Kunkel, Louis Children's Hospital Boston
Potential role of non-coding RNAs in autism Talebizadeh, Zohreh Children's Mercy Hospitals And Clinics
Genome-wide association study of autism characterized by developmental regression Molloy, Cynthia Cincinnati Children's Hospital Medical Center
Genetic basis of autism Wigler, Michael Cold Spring Harbor Laboratory
Simons Simplex Collection Site Peterson, Bradley Columbia University
Whole-genome sequencing for rare highly penetrant gene variants in schizophrenia Goldstein, David Duke University
Simons Simplex Collection Site Lese Martin, Christa Emory University
Comprehensive genetic variation detection to assess the role of the X chromosome in autism Warren, Stephen Emory University
Dense mapping of candidate regions linked to autistic disorder Gregersen, Peter Feinstein Institute For Medical Research
Population genetics to improve homozygosity mapping and mapping in admixed groups Williams, Amy Harvard Medical School
Illumina, Inc. No PI listed Illumina, Inc.
The role of retrotransposons in autism spectrum disorders Kazazian, Haig Johns Hopkins University
Understanding glutamate signaling defects in autism spectrum disorders Wang, Tao Johns Hopkins University
Integrative genetic analysis of autistic brains Arking, Dan Johns Hopkins University School of Medicine
The role of contactin-associated protein-like 2 (CNTNAP2) and other novel genes in autism Chakravarti, Aravinda Johns Hopkins University School of Medicine

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.