|Project Title||Principal Investigator||Institution|
|Integrated function/structure image analysis in autism||Duncan, James||Yale University|
|Ethnicity and the elucidation of autism endophenotypes||Constantino, John||Washington University in St. Louis|
|Executive functioning, theory of mind, and neurodevelopmental outcomes||Warren, Zachary||Vanderbilt University Medical Center|
|Early detection and intervention in infants at risk for autism||Dawson, Geraldine||University of Washington|
|Development of categorization and facial knowledge in infants at-risk for autism - AS||Strauss, Mark||University of Pittsburgh|
|Development of categorization + facial knowledge in low + high functioning autism - NIH||Strauss, Mark||University of Pittsburgh|
|Automated measurement of facial expression in autism: Deficits in facial nerve function?||Messinger, Daniel||University of Miami|
|Emotion, communication, & EEG: Development & risk||Messinger, Daniel||University of Miami|
|Motor control in young children with autism||Hass, Christopher||University of Florida|
|Sleep, neuropsychological, mood, behavior, learning, and developmental problems in children with autism||Mayes, Susan||Penn State College of Medicine|
|Clinical and behavioral phenotyping of autism and related disorders||Swedo, Susan||National Institutes of Health|
|Imitation in autism||Bolton, Patrick||King's College, London|
|Autism: Social and communication predictors in siblings||Landa, Rebecca||Kennedy Krieger Institute|
|Language processing in children with 22q11 deletion syndrome and autism||Ousley, Opal||Emory University|
|Scales, procedures, and intervention programs for estimating the prevalence of childhood disability and autism in Bangladesh||Khan, Naila||Dhaka Shishu (Children's) Hospital, Bangladesh Institute of Child Health|
|The early identification of temperament endophenotypes in ASD||Bryson, Susan||Dalhousie University|
|Temperament, emotional expression, and emotional self-regulation in relation to later ASD diagnosis||Wozniak, Robert||Bryn Mawr College|
|Understanding the cognitive impact of early life epilepsy||Jensen, Frances||Boston Children's Hospital|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015.
IACC Recommended Budget: $71,100,000 over 5 years
|1.L.B. Funding: The recommended budget was partially met.
Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.
Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.