|Project Title||Principal Investigator||Institution|
|Metabolic biomarkers of autism: Predictive potential and genetic susceptibility||James, Sandra||Arkansas Children's Hospital Research Institute|
|Neurophysiological investigation of language acquisition in infants at risk for ASD||Seery, Anne||Boston University|
|Neurobehavioral research on infants at risk for SLI and autism||Tager-Flusberg, Helen; Nelson, Charles||Boston University Medical Campus|
|Temperament, emotional expression, and emotional self-regulation in relation to later ASD diagnosis||Wozniak, Robert||Bryn Mawr College|
|Multiplexed suspension arrays to investigate newborn and childhood blood samples for potential immune biomarkers of autism||Vogt, Robert||Centers for Disease Control and Prevention (CDC)|
|RNA expression studies in autism spectrum disorders||Kunkel, Louis||Children's Hospital Boston|
|Signatures of gene expression in autism spectrum disorders||Kunkel, Louis||Children's Hospital Boston|
|Electrophysiological, metabolic and behavioral markers of infants at risk||Nelson, Charles||Children's Hospital Boston|
|Identifying gastrointestinal (GI) conditions in children with autism spectrum disorders (ASD)||Winter, Harland||Harvard Medical School|
|Identification of lipid biomarkers for autism||Kang, Jing||Massachusetts General Hospital|
|Placental vascular tree as biomarker of autism/ASD risk||Salafia, Carolyn||Research Foundation for Mental Hygiene, Inc.|
|Family/Genetic study of autism||Smith, Christopher||Southwestern Autism Research & Resource Center (SARRC)|
|Oxytocin biology and the social deficits of autism spectrum disorders||Parker, Karen||Stanford University|
|Infants at risk of autism: A longitudinal study||Ozonoff, Sally||University of California, Davis|
|ACE Center: MRI studies of early brain development in autism||Courchesne, Eric||University of California, San Diego|
|Development of neural pathways in infants at risk for autism spectrum disorders||Dobkins, Karen||University of California, San Diego|
|Development of neural pathways in infants at risk for autism spectrum disorders (supplement)||Dobkins, Karen||University of California, San Diego|
|ACE Center: Integrated Biostatistical and Bioinformatic Analysis Core (IBBAC)||Schork, Nicholas||University of California, San Diego|
|Are autism spectrum disorders associated with leaky-gut at an early critical period in development?||Dobkins, Karen; Schmid-Schoenbein, Geert||University of California, San Diego|
|ACE Center: Clinical Phenotype: Recruitment and Assessment Core||Pierce, Karen||University of California, San Diego|
|Studying the biology and behavior of autism at 1-year: The Well-Baby Check-Up approach||Pierce, Karen||University of California, San Diego|
|Abnormal vestibulo-ocular reflexes in autism: A potential endophenotype||White, Keith||University of Florida|
|Pupil size and circadian salivary variations in autism spectrum disorder||Colombo, John||University of Kansas|
|The emergence of emotion regulation in children at-risk for autism spectrum disorder||Ekas, Naomi||University of Miami|
|Validation study of atypical dynamic pupillary light reflex as a biomarker for autism||Yao, Gang; Miles, Judith; Christ, Shawn||University of Missouri|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014.
IACC Recommended Budget: $33,300,000 over 5 years
|1.L.A. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: More than 40 projects have been supported in this area, but most projects are still in the discovery phase. Identifying reliable early biomarkers has been challenging, but some progress has been made. More work is needed to achieve the full intent of the objective.
Remaining Gaps, Needs, and Opportunities: Remaining research needs include continued discovery of biomarkers, linking biomarkers to treatment response, validation of biomarkers discovered in high risk populations for applicability in the general population, and evaluation of whether these biomarkers translate to improvement in screening and diagnosis real-world settings. There is also a need for biomarkers that are cost-effective.