|Project Title||Principal Investigator||Institution|
|ACE Center: Administrative Core||Klin, Ami||Yale University|
|Observational and electrophysiological assessments of temperament in infants at risk for autism spectrum disorders||Burner, Karen||University of Washington|
|Defining high and low risk expression of emotion in infants at risk for autism||Hannigen, Sarah||University of Pittsburgh|
|Development of ventral stream organization||O'Hearn, Kirsten||University of Pittsburgh|
|A study of autism||Krieger, Abba||University of Pennsylvania|
|Functional neuroimaging of psychopharmacologic intervention for autism||Dichter, Gabriel||University of North Carolina at Chapel Hill|
|Cognitive control and social engagement among younger siblings of children with autism||Mohapatra, Leena||University of Miami|
|Language functioning in optimal outcome children with a history of autism||Fein, Deborah||University of Connecticut|
|Neuroimaging of autism spectrum disorders||Schultz, Robert||University of California, Los Angeles|
|Cerebral asymmetry and language in autism||Rojas, Donald||University of California, Los Angeles|
|Neuroimaging and symptom domains in autism||Levitt, Jennifer||University of California, Los Angeles|
|Language and social communication in autism||Siegel, Jeff||University of California, Los Angeles|
|Language and social communication in autism||Knaus, Tracey||University of California, Los Angeles|
|Assessing information processing and capacity for understanding language in non-verbal children with autism||Benasich, April; Schafer, Valerie||Rutgers, The State University of New Jersey; City University of New York|
|Innovative assessment methods for autism: A proof of principle investigation of "nonverbal" autism||Connolly, John||McMaster University|
|Early biologic markers for autism||Croen, Lisa||Kaiser Permanente Division of Research|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Launch at least three studies that evaluate the applicability of ASD phenotype and/or biological signature findings for performing diagnosis, risk assessment, or clinical intervention by 2015.
IACC Recommended Budget: $7,200,000 over 5 years
|2.L.B. Funding: The recommended budget was partially met.
Progress: Imaging studies have developed activity signatures of the ASD brain. While more than 3 studies were launched, more funding and work in this area are needed.
Remaining Gaps, Needs and Opportunities: This objective also requires standardization of data collection and analysis methods, as well as collaboration among investigators to pool data. Increased emphasis must be placed on conducting biological evaluations of very young children at risk for ASD and on collecting biological samples from these young children, to enable research into the establishment of biomarkers or risk markers in this population.