Strategic Plan Objective Detail
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Question 2: Short-term Objective A  

$4,972,407.28
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Download 2010 Question 2: Short-term Objective A projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Systematic characterization of the immune response to gluten and casein in autism spectrum disorders Alaedini, Armin Weill Cornell Medical College
A primate model of gut, immune, and CNS response to childhood vaccines Sackett, Gene University of Washington
Neurological diseases due to inborn errors of metabolism Pascual, Juan University of Texas Southwestern Medical Center
An ex-vivo placental perfusion system to study materno-fetal biology Bonnin, Alexandre University of Southern California
CNS toxicity of ambient air pollution: Postnatal exposure to ultrafine particles Cory-Slechta, Deborah University of Rochester
Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development Noble, Mark University of Rochester
Study of anti-neuronal autoantibodies in behavioral and movement disorders Cunningham, Madeleine University of Oklahoma Health Sciences Center
Molecular pathways involved in oxidative stress and leaky gut impairment in autism spectrum disorders Antonucci, Nicola University of Naples
Influence of maternal cytokines on activation of the innate immune system as a factor in the development of autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Influence of the maternal immune response on the development of autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Prostaglandins and cerebellum development McCarthy, Margaret University of Maryland, Baltimore
Primate models of autism Bauman, Melissa University of California, Davis
Project 2: Immunological susceptibility of autism Van de Water, Judy University of California, Davis
Primate models of autism Bauman, Melissa; Amaral, David University of California, Davis
A role for immune molecules in cortical connectivity: Potential implications for autism Elmer, Bradford University of California, Davis
Is autism a mitochondrial disease? Giulivi, Cecilia University of California, Davis
Maternal immune activation, cytokines, and the pathogenesis of autism McAllister, A. Kimberley University of California, Davis
Immune molecules and cortical synaptogenesis: Possible implications for the pathogenesis of autism McAllister, A. Kimberley University of California, Davis
A non-human primate autism model based on maternal immune activation Patterson, Paul University of California, Davis
EFRI- BSBA: Novel microsystems for manipulation and analysis of immune cells Revzin, Alexander University of California, Davis
The effect of mercury and neuropeptide triggers on human mast cell release of neurotoxic molecules Theohardies, Theoharis Tufts University
Does mercury and neurotension induce mitochondrial DNA release from human mast cells and contribute to auto-immunity in ASD? Theohardies, Theoharis Tufts University
Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance Rall, Glenn The Fox Chase Cancer Center
The pathogenesis of autism: Maternal antibody exposure in the fetal brain Diamond, Betty The Feinstein Institute for Medical Research