Strategic Plan Objective Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Question 2: Short-term Objective E  

$4,611,057.50
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective E projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
The effects of disturbed sleep on sleep-dependent memory consolidation and daily function in individuals with ASD Stickgold, Robert Beth Israel Deaconess Medical Center
Understanding the cognitive impact of early life epilepsy Jensen, Frances Children's Hospital Boston
Selective disruption of hippocampal dentate granule cells in autism: Impact of PTEN deletion Danzer, Steve Cincinnati Children's Hospital Medical Center
Treatment of medical conditions among individuals with autism spectrum disorders Swedo, Susan National Institutes of Health
Neural dissection of hyperactivity/inattention in autism Castellanos, Francisco New York University School of Medicine
Molecular components of A-type K+ channels Rudy, Bernardo New York University School of Medicine
Characterizing sleep disorders in autism spectrum disorder O'Hara, Ruth Stanford University
Gastrointestinal functions in autism Duffey, Michael University at Buffalo, The State University of New York
Etiology of sleep disorders in ASD: Role of inflammatory cytokines Mong, Jessica University of Maryland, Baltimore
Th cell polarization and candida reactivity in autistic children with food allergy Jyonouchi, Harumi University of Medicine & Dentistry of New Jersey
Sensory mechanisms and self-injury Symons, Frank University of Minnesota
The MET signaling system, autism and gastrointestinal dysfunction Levitt, Pat University of Southern California
ACE Center: Structural and chemical brain imaging of autism Dager, Stephen University of Washington
Relation of sleep epileptiform discharges to insomnia and daytime behavior Barnes, Gregory Vanderbilt University

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012.

IACC Recommended Budget: $9,000,000 over 5 years
N/A

2.S.E
$3,893,300
11 projects

2.S.E
$4,611,058
14 projects

2.S.E
$4,807,760
23 projects

2.S.E
$3,218,960
22 projects

$16,531,078
2.S.E. Funding: The recommended budget for this objective was met.

Progress: More than twenty projects were funded that were specific to this objective. Scientific advances in this area include mechanistic and mutation linkages of epilepsy and ASD-like behaviors, as well as circadian rhythm disruptions downstream of ASD-associated mutations.

Remaining Gaps, Needs and Opportunities: While studies on co-occurring conditions have been initiated, a greater depth of understanding is needed. Further efforts are needed, especially on wandering, metabolic and immune conditions related to ASD, as well as a systems-biology approach to understand how these co-occurring conditions are related to ASD. In order to more accurately assess progress, wandering/elopement should be considered separately from seizures/epilepsy/sleep. Familial autoimmune disorders could be moved to 2.S.A to be grouped with other immune-related issues.