|Project Title||Principal Investigator||Institution|
|The effects of disturbed sleep on sleep-dependent memory consolidation and daily function in individuals with ASD||Stickgold, Robert||Beth Israel Deaconess Medical Center|
|Understanding the cognitive impact of early life epilepsy||Jensen, Frances||Children's Hospital Boston|
|Selective disruption of hippocampal dentate granule cells in autism: Impact of PTEN deletion||Danzer, Steve||Cincinnati Children's Hospital Medical Center|
|Treatment of medical conditions among individuals with autism spectrum disorders||Swedo, Susan||National Institutes of Health|
|Neural dissection of hyperactivity/inattention in autism||Castellanos, Francisco||New York University School of Medicine|
|Molecular components of A-type K+ channels||Rudy, Bernardo||New York University School of Medicine|
|Characterizing sleep disorders in autism spectrum disorder||O'Hara, Ruth||Stanford University|
|Gastrointestinal functions in autism||Duffey, Michael||University at Buffalo, The State University of New York|
|Etiology of sleep disorders in ASD: Role of inflammatory cytokines||Mong, Jessica||University of Maryland, Baltimore|
|Th cell polarization and candida reactivity in autistic children with food allergy||Jyonouchi, Harumi||University of Medicine & Dentistry of New Jersey|
|Sensory mechanisms and self-injury||Symons, Frank||University of Minnesota|
|The MET signaling system, autism and gastrointestinal dysfunction||Levitt, Pat||University of Southern California|
|ACE Center: Structural and chemical brain imaging of autism||Dager, Stephen||University of Washington|
|Relation of sleep epileptiform discharges to insomnia and daytime behavior||Barnes, Gregory||Vanderbilt University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012.
IACC Recommended Budget: $9,000,000 over 5 years
|2.S.E. Funding: The recommended budget for this objective was met.
Progress: More than twenty projects were funded that were specific to this objective. Scientific advances in this area include mechanistic and mutation linkages of epilepsy and ASD-like behaviors, as well as circadian rhythm disruptions downstream of ASD-associated mutations.
Remaining Gaps, Needs and Opportunities: While studies on co-occurring conditions have been initiated, a greater depth of understanding is needed. Further efforts are needed, especially on wandering, metabolic and immune conditions related to ASD, as well as a systems-biology approach to understand how these co-occurring conditions are related to ASD. In order to more accurately assess progress, wandering/elopement should be considered separately from seizures/epilepsy/sleep. Familial autoimmune disorders could be moved to 2.S.A to be grouped with other immune-related issues.