|Project Title||Principal Investigator||Institution|
|Neurogenic growth factors in autism||Vaccarino, Flora||Yale University|
|Longitudinal neurogenetics of atypical social brain development in autism||Pelphrey, Kevin||Yale University|
|Autistic traits: Life course & genetic structure||Constantino, John||Washington University|
|Simons Variation in Individuals Project (VIP) Site||Bernier, Raphael||University of Washington|
|Social processing, language, and executive functioning in twin pairs: Electrophysiological and behavioral endophenotypes||Webb, Sara||University of Washington|
|ACE Center: Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|An investigation of the overlap of autism and fragile X syndrome||Martin, Gary||University of North Carolina at Chapel Hill|
|A multigenerational longitudinal study of language development: Insight from autism||Losh, Molly||University of North Carolina at Chapel Hill|
|A family-genetic study of language in autism||Losh, Molly||University of North Carolina at Chapel Hill|
|Neural circuitry of social cognition in the broad autism phenotype||Piven, Joseph||University of North Carolina at Chapel Hill|
|fMRI evidence of genetic influence on rigidity in ASD||Lee, Jillian||University of Michigan|
|Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD||Monk, Christopher||University of Michigan|
|ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes||Cook, Edwin||University of Illinois at Chicago|
|Autism: Neuropeptide hormones and potential pathway genes (supplement)||Jacob, Suma||University of Illinois at Chicago|
|Autism: Neuropeptide hormones and potential pathway genes||Jacob, Suma||University of Illinois at Chicago|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models||Dulawa, Stephanie||University of Chicago|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement)||Dulawa, Stephanie||University of Chicago|
|The genetic link between autism and structural cerebellar malformations||Millen, Kathleen||University of Chicago|
|Simons Variation in Individuals Project (Simons VIP) Core Leader Gift||Sherr, Elliott||University of California, San Francisco|
|Relating copy number variants to head and brain size in neuropsychiatric disorders||Sebat, Jonathan||University of California, San Diego|
|Neural and phenotypic correlates of autism risk genes||Bookheimer, Susan||University of California, Los Angeles|
|ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition||Geschwind, Daniel||University of California, Los Angeles|
|Social cognition in 22q11.2 deletion syndrom (DS) adolescents with ASD vs. without ASD: Imaging and genetic correlates||Radoeva, Petya||State University of New York Upstate Medical University|
|A neuroimaging study of twin pairs with autism||Hardan, Antonio||Stanford University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.
IACC Recommended Budget: $22,600,000 over 5 years
|2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.
Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.