|Project Title||Principal Investigator||Institution|
|Autism: The neural substrates of language in siblings||Lindgren, Kristen||Boston University Medical Campus|
|Simons Variation in Individual Project (Simons VIP) Core Leader Gift||Hanson, Ellen||Children's Hospital Boston|
|Functional imaging of flexibility in autism: Informed by SLC6A4||Yerys, Benjamin||Children's Research Institute|
|Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift||Chung, Wendy||Columbia University|
|Simons Variation in Individuals Project (Simons VIP)||Lese Martin, Christa||Emory University|
|Language processing in children with 22q11 deletion syndrome and autism||Ousley, Opal||Emory University|
|Characterizing the genetic systems of autism through multi-disease analysis||Wall, Dennis||Harvard Medical School|
|Neural correlates of restricted, repetitive behaviors in autism spectrum disorders||Manoach, Dara||Massachusetts General Hospital|
|Neural correlates of restricted, repetitive behaviors in autism spectrum disorders||Santangelo, Susan||Massachusetts General Hospital|
|A multigenerational longitudinal study of language development: Insight from autism||Losh, Molly||Northwestern University|
|A family-genetic study of language in autism||Losh, Molly||Northwestern University|
|The brain genomics superstruct project||Buckner, Randy||President & Fellows of Harvard College|
|Behavioral and genetic biomarker development for autism and related disorders||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|The genetic basis of mid-hindbrain malformations||Dobyns, William||Seattle Children's Hospital|
|A neuroimaging study of twin pairs with autism||Hardan, Antonio||Stanford University|
|Social cognition in 22q11.2 deletion syndrom (DS) adolescents with ASD vs. without ASD: Imaging and genetic correlates||Radoeva, Petya||State University of New York Upstate Medical University|
|Neural and phenotypic correlates of autism risk genes||Bookheimer, Susan||University of California, Los Angeles|
|ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition||Geschwind, Daniel||University of California, Los Angeles|
|Relating copy number variants to head and brain size in neuropsychiatric disorders||Sebat, Jonathan||University of California, San Diego|
|Simons Variation in Individuals Project (Simons VIP) Core Leader Gift||Sherr, Elliott||University of California, San Francisco|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models||Dulawa, Stephanie||University of Chicago|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement)||Dulawa, Stephanie||University of Chicago|
|The genetic link between autism and structural cerebellar malformations||Millen, Kathleen||University of Chicago|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes||Cook, Edwin||University of Illinois at Chicago|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.
IACC Recommended Budget: $22,600,000 over 5 years
|2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.
Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.