|Project Title||Principal Investigator||Institution|
|Influence of the maternal immune response on the development of autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Influence of maternal cytokines on activation of the innate immune system as a factor in the development of autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Interactions of environment and molecular pathways on brain overgrowth in autism: Maternal inflammation and the PI3/AKT pathway||Lebelle, Janel||University of California, Los Angeles|
|Immunobiology in autism||Van de Water, Judy||University of California, Davis|
|Project 1: Environmental epidemiology of autism||Hertz-Picciotto, Irva||University of California, Davis|
|Early developmental risk factors for autism in a national birth cohort||Sourander, Andre||Turku University|
|Assisted reproductive treatments and risk of autism||Reichenberg, Avi||Institute of Psychiatry, King's College London|
|Maternal risk factors for autism in the Nurses Health Study II – pilot study||Ascherio, Alberto||Harvard School of Public Health|
|Maternal dietary factors and risk of ASDs||Santangelo, Susan||Harvard Medical School|
|Social determinants of the autism epidemic||Bearman, Peter||Columbia University|
|Immune biomarkers in serum and newborn dried blood spots||No PI listed||Centers for Disease Control and Prevention|
|Maternal supplementation of folic acid and function of autism gene synaptic protein Shank3 in animal model||Jiang, Yong-Hui||Baylor College of Medicine|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the prenatal and early postnatal period of development by 2015.
IACC Recommended Budget: $25,100,000 over 7 years
|3.L.C. Funding: The recommended budget was partially met, and several projects were funded, but it appears there is a downward trend in funding for these projects over time. This objective partially overlaps with 3.L.A.
Progress: Epidemiological studies coded to other objectives (e.g., EARLI) may also represent progress in this area.
Remaining Gaps, Needs, and Opportunities: Â A barrier to the completion of this objective is the undefined nature of ASD subtypes, both phenotypically and etiologically, lack of prenatal samples, and the lack of longitudinal follow-up of at-risk subgroups. This field is still developing and needs support.