|Project Title||Principal Investigator||Institution|
|A genome-wide search for autism genes in the Simons Simplex Collection||State, Matthew||Yale University|
|Simons Simplex Collection Site - 7||Klin, Ami||Yale University|
|Simons Simplex Collection Site - 3||Constantino, John||Washington University in St. Louis|
|Simons Simplex Collection Site - 12||Sutcliffe, James||Vanderbilt University|
|Genetic analysis of 15q11-q13 in autism||Sutcliffe, James||Vanderbilt University|
|Unraveling the genetic etiology of autism||Sutcliffe, James||Vanderbilt University|
|Simons Simplex Collection Site - 2||Bernier, Raphael||University of Washington|
|Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|Proteomics in Drosophila to identify autism candidate substrates of UBE3A||Reiter, Lawrence||University of Tennessee Health Science Center|
|Center for genomic and phenomic studies in autism||Lajonchere, Clara||University of Southern California|
|Neurobiology of sociability in a mouse model system relevant to autism||Brodkin, Edward||University of Pennsylvania|
|Identifying and understanding the action of autism susceptibility genes||Monaco, Anthony||University of Oxford|
|Neural circuitry of social cognition in the broad autism phenotype||Piven, Joseph||University of North Carolina at Chapel Hill|
|A molecular genetic study of autism and related phenotypes in extended pedigrees||Piven, Joseph||University of North Carolina at Chapel Hill|
|Simons Simplex Collection Site - 10||Miles, Judith||University of Missouri|
|Simons Simplex Collection Site - 9||Lord, Catherine||University of Michigan|
|Identification and functional assessment of autism susceptibity genes - 2||Millonig, James||University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School|
|Simons Simplex Collection Site - 14||Deutsch, Curtis||University of Massachusetts Medical School|
|Simons Simplex Collection Site - 4||Cook, Edwin||University of Illinois at Chicago|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Genetic study of restricted repetitive behavior in autism spectrum disorders||Kim, Soo-Jeong||University of Florida|
|Genomic imbalances in autism - AS||Kumar, Ravinesh||University of Chicago|
|Genomic imbalances in autism - NIH||Christian, Susan||University of Chicago|
|Role of micro-RNAs in ASD affected circuit formation and function||Ullian, Erik||University of California, San Francisco|
|Demonstration of the novel RASL/DASL method for analysis of gene expression in frontal cortex in autism and control cases||Courchesne, Eric||University of California, San Diego|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.