|Project Title||Principal Investigator||Institution|
|Autism Genetic Resource Exchange (AGRE)||Lajonchere, Clara||Autism Speaks|
|Autism Genome Project (AGP)||Shih, Andy||Autism Speaks|
|The role of the Rett gene, chromosome 15q11-q13, other genes, and epigenetics||Beaudet, Arthur||Baylor College of Medicine|
|Studies of postmortem brain searching for epigenetic defects causing autism||Beaudet, Arthur||Baylor College of Medicine|
|Simons Simplex Collection Site - 1||Beaudet, Arthur||Baylor College of Medicine|
|Mutation analysis of candidate genes derived from an autism protein interaction network in SSC autism samples||Zoghbi, Huda||Baylor College of Medicine|
|Recessive genes for autism and mental retardation||Walsh, Christopher||Beth Israel Deaconess Medical Center|
|Uncovering genetic mechanisms of ASD||Kunkel, Louis||Boston Children's Hospital|
|Gene expression profiling of autism spectrum disorders||Collins, Christin||Boston Children's Hospital|
|Simons Simplex Collection Site - 13||Walsh, Christopher||Boston Children's Hospital|
|Gene finding - 2||Walsh, Christopher||Boston Children's Hospital|
|Neuronal populations related to deficits in social emotions and cognition in autism: A neurobiological and genomics approach||Allman, John||California Institute of Technology|
|Identification of autism candidate genes on the X-chromosome from copy number variants identified by 500K SNP-CHIP analysis||Vincent, John||Centre For Addiction And Mental Health|
|Potential role of noncoding RNAs in autism||Talebizadeh, Zohreh||Children's Mercy Hospitals and Clinics|
|Determining the genetic basis of autism by hi-resolution analysis of copy number||Sebat, Jonathan||Cold Spring Harbor Laboratory|
|Genetic basis of autism||Wigler, Michael||Cold Spring Harbor Laboratory|
|Core--genomics/bioinformatics--Alzheimer's disease and autism||Gilliam, Thomas||Columbia University|
|Simons Simplex Collection Site - 11||Peterson, Bradley||Columbia University|
|Isolation of autism susceptibility genes||Stefansson, Kari||Decode Genetics, Inc.|
|Molecular analysis core||Pericak-Vance, Margaret||Duke University|
|Neurogenetics of candidate systems in autism||Haines, Jonathan||Duke University|
|Clinical and bioinformatics core||Pericak-Vance, Margaret||Duke University|
|Genetic studies in autism on chromosome 7||Pericak-Vance, Margaret||Duke University|
|Genomic resources for identifying genes regulating social behavior||Young, Larry||Emory University|
|Identifying autism susceptibility genes by high-throughput chip resequencing||Zwick, Michael||Emory University|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.