|Project Title||Principal Investigator||Institution|
|Whole-genome sequencing for rare highly penetrant gene variants in schizophrenia||Goldstein, David||Duke University|
|Epigenetic marks as peripheral biomarkers of autism||Warren, Stephen||Emory University|
|Discordant monozygotic twins as a model for genetic-environmental interaction in autism||Feinberg, Andrew||Johns Hopkins University|
|Environment, the perinatal epigenome, and risk for autism and related disorders||Fallin, Margaret Danielle||Johns Hopkins University|
|Genome-wide environment interaction study for autism: The SEED study||Fallin, Margaret Danielle||Johns Hopkins University|
|Discordant monozygotic twins as a model for genetic-environmental interaction in autism||Kaufmann, Walter||Kennedy Krieger Institute|
|Prenatal factors and risk of autism in a Finnish national birth cohort||Brown, Alan||New York State Psychiatric Institute|
|The CHARGE Study: Childhood Autism Risks from Genetics and the Environment||Hertz-Picciotto, Irva||University of California, Davis|
|Genetics and gene-environment interactions in a Korean epidemiological sample of autism||Kim, Young Shin||Yale University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene-environment research by 2011. |
IACC Recommended Budget: $27,800,000 over 5 years
|3.S.C. Funding: The recommended budget was nearly met, but work still needs to continue on this objective. |
Progress: The funding allocated to this area so far has primarily supported building infrastructure that can now be expanded to include more subjects, more data, and more analytical projects. Studies such as the MARBLES (Markers of Autism Risk in Babies Learning Early Signs) cohort study and the CHARGE (Childhood Autism Risks from Genetics and the Environment) study are included under this objective.
Remaining Gaps, Needs, and Opportunities: Continued benefit will be derived from past investments as these resources are expanded and pooled.