|Project Title||Principal Investigator||Institution|
|Immunopathogenesis in autism: Regulatory T cells and autoimmunity in neurodevelopment||DeWitt, Jamie||East Carolina University|
|Prenatal exposure to polyfluoroalkyl compounds in the EMA study||Croen, Lisa||Kaiser Foundation Research Institute|
|MeHG stimulates antiapoptotic signaling in stem cells||Bressler, Joseph||Kennedy Krieger Institute|
|Early exposure to acetaminophen and autism||Hertz-Picciotto, Irva||University of California, Davis|
|An investigation on the potential harmful effects of mercury in the nonhuman primate||Burbacher, Thomas||University of Washington|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. |
IACC Recommended Budget: $56,000,000 over 2 years (revised in 2010)
|3.S.F. Funding: The recommended budget was partially met. |
Progress: There has been a significant decrease in the number of studies related to this objective.
Remaining Gaps, Needs, and Opportunities: Further work in this area is needed, and work should focus on identifying the directionality of associations between environmental factors and ASD (causal, reactive, or independent) in order to be applied to prevention and the development of therapeutics. Sophisticated methods that are being applied in other fields need to be brought into autism research.