|Project Title||Principal Investigator||Institution|
|Human intestinal microbial ecology and its relationship to autism||Krajmalnik-Brown, Rosa||Biodesign Institute, Arizona State University|
|Analysis of the small intestinal microbiome of children with autism||Kushak, Rafail||Massachusetts General Hospital|
|Elevated urinary P-cresol: Intestinal causes and behavioral consequences||Persico, Antonio||Universita Campus Bio-Medico di Roma|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support at least two studies that examine potential differences in the microbiome of individuals with ASD versus comparison groups by 2012.
IACC Recommended Budget: $1,000,000 over 2 years
|3.S.I. Funding: The recommended budget was partially met.
Progress: The number of projects in this area has been growing, with 6 projects in 2012. The number of funded projects is large relative to the amount of funding, indicating that each of the projects is small, which suggests that these projects will not be sufficient in scope to complete this objective.
Remaining Gaps, Needs, and Opportunities: The high cost of required technology could be a barrier to the completion of this objective. These smaller pilot studies are potentially underpowered. The question of sample availability is important for this objective, along with raising researcher awareness of sample repositories.