Strategic Plan Objective Detail
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Question 3: Short-term Objective J  

$5,072,389.28
Fiscal Year: 2010

New! Green dot: Objective has greater than or equal to the recommended funding.3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Download 2010 Question 3: Short-term Objective J projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Human neurobehavioral phenotypes associates with the extended PWS/AS domain Beaudet, Arthur Baylor College of Medicine
The role of the Rett gene, chromosome 15q11-q13, other genes, and epigenetics Beaudet, Arthur Baylor College of Medicine
Maternal supplementation of folic acid and function of autism gene synaptic protein Shank3 in animal model Jiang, Yong-Hui Baylor College of Medicine
Studies of postmortem brain searching for epigenetic defects causing autism Beaudet, Arthur Baylor College of Medicine
DNA methylation and other epigenetic studies of autism brain Beaudet, Arthur Baylor College of Medicine
Epigenetic marks as peripheral biomarkers of autism Warren, Stephen Emory University
Environment, the perinatal epigenome, and risk for autism and related disorders Fallin, Margaret; Feinberg, Andrew Johns Hopkins University
Discordant monozygotic twins as a model for genetic-environmental interaction in autism Feinberg, Andrew Johns Hopkins University
Discordant monozygotic twins as a model for genetic-environmental interaction in autism Kaufmann, Walter Kennedy Krieger Institute
Identical twins discordant for autism: Epigenetic (DNA methylation) biomarkers of non-shared environmental influences Plomin, Robert King's College London
Genome-wide analyses of DNA methylation in autism Chess, Andrew Massachusetts General Hospital
Identification of aberrantly methylated genes in autism: The role of advanced paternal age Gingrich, Jay Research Foundation for Mental Hygiene, Inc.
Toxicant-induced autism and mitochondrial modulation of nuclear gene expression Wlodarczyk, Bogdan Texas A&M University
Epigenetic regulation of the autism susceptibility gene, ENGRAILED 2 (EN2) Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
In vivo function of neuronal activity-induced MeCP2 phosphorylation Chang, Qiang University of Wisconsin - Madison

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012.

IACC Recommended Budget: $20,000,000 over 5 years
N/A

N/A

3.S.J
$5,072,389
15 projects

3.S.J
$5,341,237
19 projects

3.S.J
$6,122,724
22 projects

$16,536,350
3.S.J. Funding: The recommended budget was partially met, and the annualized recommended budget targets were met for all 3 years since the objective was introduced; therefore, the funding for this objective is on track. If this funding trend continues, the objective's recommended budget will be met within the recommended 5 year timeframe.

Progress: More than the recommended number of projects have been funded, with 22 projects supported in 2012. This is a growing area of research, and the current momentum in this area should be maintained.

Remaining Gaps, Needs, and Opportunities: An important technological need for this objective is the development of robust epigenetic measurements for small biological samples, such a blood spots. A possible barrier to research in this area is the availability and preservation quality of these samples. Large funded studies such as MARBLES might provide an opportunity to collect samples. If samples are made available, that may catalyze research in this area.