|Project Title||Principal Investigator||Institution|
|In vivo function of neuronal activity-induced MeCP2 phosphorylation||Chang, Qiang||University of Wisconsin - Madison|
|Epigenetic regulation of the autism susceptibility gene, ENGRAILED 2 (EN2)||Millonig, James||University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School|
|Toxicant-induced autism and mitochondrial modulation of nuclear gene expression||Wlodarczyk, Bogdan||Texas A&M University|
|Identification of aberrantly methylated genes in autism: The role of advanced paternal age||Gingrich, Jay||Research Foundation for Mental Hygiene, Inc.|
|Genome-wide analyses of DNA methylation in autism||Chess, Andrew||Massachusetts General Hospital|
|Identical twins discordant for autism: Epigenetic (DNA methylation) biomarkers of non-shared environmental influences||Plomin, Robert||King's College London|
|Discordant monozygotic twins as a model for genetic-environmental interaction in autism||Kaufmann, Walter||Kennedy Krieger Institute|
|Environment, the perinatal epigenome, and risk for autism and related disorders||Fallin, Margaret; Feinberg, Andrew||Johns Hopkins University|
|Discordant monozygotic twins as a model for genetic-environmental interaction in autism||Feinberg, Andrew||Johns Hopkins University|
|Epigenetic marks as peripheral biomarkers of autism||Warren, Stephen||Emory University|
|Studies of postmortem brain searching for epigenetic defects causing autism||Beaudet, Arthur||Baylor College of Medicine|
|Human neurobehavioral phenotypes associates with the extended PWS/AS domain||Beaudet, Arthur||Baylor College of Medicine|
|The role of the Rett gene, chromosome 15q11-q13, other genes, and epigenetics||Beaudet, Arthur||Baylor College of Medicine|
|DNA methylation and other epigenetic studies of autism brain||Beaudet, Arthur||Baylor College of Medicine|
|Maternal supplementation of folic acid and function of autism gene synaptic protein Shank3 in animal model||Jiang, Yong-Hui||Baylor College of Medicine|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012.
IACC Recommended Budget: $20,000,000 over 5 years
|3.S.J. Funding: The recommended budget was partially met, and the annualized recommended budget targets were met for all 3 years since the objective was introduced; therefore, the funding for this objective is on track. If this funding trend continues, the objective's recommended budget will be met within the recommended 5 year timeframe.
Progress: More than the recommended number of projects have been funded, with 22 projects supported in 2012. This is a growing area of research, and the current momentum in this area should be maintained.
Remaining Gaps, Needs, and Opportunities: An important technological need for this objective is the development of robust epigenetic measurements for small biological samples, such a blood spots. A possible barrier to research in this area is the availability and preservation quality of these samples. Large funded studies such as MARBLES might provide an opportunity to collect samples. If samples are made available, that may catalyze research in this area.