|Project Title||Principal Investigator||Institution|
|Models and mechanisms - 2||Sahin, Mustafa||Boston Children's Hospital|
|Genetic analyses of ARX homeobox gene function in neurodevelopmental disorders||Sengupta, Piali||Brandeis University|
|Oxidative stress: Rat study||Sajdel-Sulkowska, Ellen||Brigham and Women's Hospital|
|A non-human primate autism model based on maternal infection||Patterson, Paul||California Institute of Technology|
|Cellular and molecular alterations in gabaergic inhibitory circuits by mutations in MECP2, a gene implicated in the Rett syndrome of the autism spectrum disorders||Huang, Z. Josh||Cold Spring Harbor Laboratory|
|Novel models to define the genetic basis of autism||Mills, Alea||Cold Spring Harbor Laboratory|
|Neurexin-neuroligin trans-syanptic interaction in learning and memory||Kandel, Eric||Columbia University|
|Genomic imbalances at the 22q11 locus and predisposition to autism||Gogos, Joseph||Columbia University|
|Distinct function of the neuroligin 3 postsynaptic adhesion complex||Budreck, Elaine||Columbia University|
|Molecular determinants of L-type calcium channel gating||Colecraft, Henry||Columbia University|
|Cognitive mechanisms of serially organized behavior||Terrace, Herbert||Columbia University|
|Aberrant synaptic function due to TSC mutation in autism||Sulzer, David||Columbia University Medical Center|
|Role of UBE3A in neocortical plasticity and function||Ehlers, Michael||Duke University|
|Synaptic and circuitry mechanisms of repetitive behaviors in autism||Feng, Guoping||Duke University Medical Center|
|Perturbed activity dependent plasticity mechanisms in autism||Sabatini, Bernardo||Harvard Medical School|
|Connectopathic analysis of autism||Sanes, Joshua||Harvard University|
|Investigation of the role of MET kinase in autism||Dawson, Ted||Johns Hopkins University School of Medicine|
|Models and mechanisms - 1||Sur, Mriganka||Massachusetts Institute of Technology|
|Mice lacking Shank postsynaptic scaffolds as an animal model of autism||Sheng, Morgan||Massachusetts Institute of Technology|
|Neural and cognitive mechanisms of autism||Sur, Mriganka||Massachusetts Institute of Technology|
|Regulation of synaptogenesis by cyclin dependent kinase 5||Tsai, Li-Huei||Massachusetts Institute of Technology|
|The role of Shank3 in autism spectrum disorders||Buxbaum, Joseph||Mount Sinai School of Medicine|
|Animal models of neuropsychiatric disorders||Crawley, Jacqueline||National Institutes of Health|
|Regulation of gene expression in the brain||Young, Walter||National Institutes of Health|
|The functional neuroanatomy of memory systems in the human brain||Martin, Alex||National Institutes of Health|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.
IACC Recommended Budget: $75,000,000 over 5 years
|4.S.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: More than 90 projects were supported to develop animal models.
Remaining Gaps, Needs, and Opportunities: Planning Group members discussed whether the amount of investment in this area is appropriate when compared to investments in clinical trials and other later stage studies. Invited experts suggested that the current stage of scientific research in ASD requires pre-clinical research to identify targets from animal and cellular models. Similar to cancer treatment development pathways, which spanned 20-30 years, research in ASD must invest in model systems to understand the fundamental biology from which translation to the clinic can be built.Â The translational validity of research in non-human animals cannot be determined until human trials are conducted, thus the need for rapid progress to clinical studies in humans is important.