|Project Title||Principal Investigator||Institution|
|Treatment of autism spectrum disorders with a glutamate antagonist||Swedo, Susan||National Institutes of Health|
|Self-management of daily living skills: Development of cognitively accessible software for individuals with autism||Keating, Thomas||Eugene Research Institute|
|Comparison of high to low intensity behavioral intervention||Granpeesheh, Doreen||Center for Autism and Related Disorders|
|Autism Treatment Network (ATN)||Jones, Nancy||Autism Speaks|
|Clinical Trials Network (CTN)||Jones, Nancy||Autism Speaks|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Complete two multi-site randomized controlled trials of comprehensive early intervention that address core symptoms, family functioning and community involvement by 2013.
IACC Recommended Budget: $16,700,000 over 5 years
|4.S.D. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: In 2011 and 2012, ~20 trials were supported, including a mix of trial sizes.Â
Remaining Gaps, Needs, and Opportunities: There is a need for both small, pilot studies and larger, robustly powered studies in this area. Several larger studies in the past few years (e.g., Early Start Denver Model) have emerged, but most studies in this area are generally smaller than in other fields of medicine and therefore lack the power to be informative if negative or definitive if positive. This objective also cites "family functioning" and "community living," which may have significant overlap with objectives in Questions 5 and 6 of the Strategic Plan.